B6.Cg-Tg(tetO-Gja1,-EGFP)L11Kwi/Cnrm

Status	Available to order
EMMA ID	EM:02594
Citation information	RRID:IMSR_EM:02594 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.Cg-Tg(tetO-Gja1,-EGFP)L11Kwi/Cnrm
Alternative name	Cx43tetOeGFP
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(tetO-Gja1,-EGFP)L11Kwi
Gene/Transgene symbol	Tg(tetO-Gja1,-EGFP)L11Kwi

Information from provider

Provider	Klaus WILLECKE
Provider affiliation	Molekulargenetik, Institut fuer Genetik, Universitaet Bonn
Genetic information	The transgene contains a bidirectional tetracycline responsive promoter flanked on one side by the Cx43 (Gja1) coding region and on the other side by the eGFP coding region. Expression of a tetracycline transactivator leads to the expression of Cx43 and eGFP, respectively.
Phenotypic information	No obvious phenotype could be detected.
Breeding history	Founder animals were backcrossed to C57BL/6 more than five times.
References	Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia.;Roell Wilhelm, Lewalter Thorsten, Sasse Philipp, Tallini Yvonne N, Choi Bum-Rak, Breitbach Martin, Doran Robert, Becher Ulrich M, Hwang Seong-Min, Bostani Toktam, von Maltzahn Julia, Hofmann Andreas, Reining Shaun, Eiberger Britta, Gabris Bethann, Pfeifer Alexander, Welz Armin, Willecke Klaus, Salama Guy, Schrickel Jan W, Kotlikoff Michael I, Fleischmann Bernd K, ;2007;Nature;450;819-24; 18064002
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	not known
Immunocompromised	not known

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Literature references

Engraftment of connexin 43-expressing cells prevents post-infarct arrhythmia.;Roell Wilhelm, Lewalter Thorsten, Sasse Philipp, Tallini Yvonne N, Choi Bum-Rak, Breitbach Martin, Doran Robert, Becher Ulrich M, Hwang Seong-Min, Bostani Toktam, von Maltzahn Julia, Hofmann Andreas, Reining Shaun, Eiberger Britta, Gabris Bethann, Pfeifer Alexander, Welz Armin, Willecke Klaus, Salama Guy, Schrickel Jan W, Kotlikoff Michael I, Fleischmann Bernd K, ;2007;Nature;450;819-24; 18064002

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