B6;129S7-Tbx1tm1(Fgf8)Vite/Cnrm

Status

Available to order

EMMA IDEM:02597
International strain nameB6;129S7-Tbx1tm1(Fgf8)Vite/Cnrm
Alternative nameTbx1fgf8
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolTbx1tm1(Fgf8)Vite,
Gene/Transgene symbolTbx1

Information from provider

ProviderAntonio BALDINI
Provider affiliationInstitute of Genetics and Biophysics (IGB), National Research Council (CNR)
Genetic informationAn Fgf8 cDNA was knocked-in to the Tbx1 locus so that it is expressed in the Tbx1 expression domain. The insertion also knocks out the Tbx1 allele.
Phenotypic informationThese animals have the haploinsufficiency phenotype of Tbx1+/- animals (low penetrance of cardiovascular defects) and relatively high penetrance of Fgf8 ectopic expression, which is manifested by a "cork-screw" tail, and that, in most severe cases, may interfere with mating.
Breeding historySibling crosses.
References
  • Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants.;Vitelli Francesca, Zhang Zhen, Huynh Tuong, Sobotka Angela, Mupo Annalisa, Baldini Antonio, ;2006;Developmental biology;295;559-70; 16696966
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal interventricular septum morphology / MGI
  • persistent truncus arteriosis / MGI
  • abnormal semilunar valve morphology / MGI
  • abnormal pharyngeal arch morphology / MGI
  • double aortic arch / MGI
  • absent pharyngeal arch arteries / MGI
  • kyphosis / MGI
  • kinked tail / MGI
  • postnatal lethality / MGI
  • abnormal cervical vertebrae morphology / MGI
  • curly tail / MGI
  • abnormal aortic arch morphology / MGI
  • interrupted aortic arch / MGI
  • retroesophageal right subclavian artery / MGI
  • cervical aortic arch / MGI
  • abnormal vertebral arch morphology / MGI
  • abnormal cervical atlas morphology / MGI
  • abnormal cervical axis morphology / MGI
  • fusion of vertebral bodies / MGI
  • absent vertebral body / MGI
  • abnormal arcus anterior morphology / MGI
  • fourth pharyngeal arch hypoplasia / MGI
  • fourth pharyngeal arch artery hypoplasia / MGI

Literature references

  • Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants.;Vitelli Francesca, Zhang Zhen, Huynh Tuong, Sobotka Angela, Mupo Annalisa, Baldini Antonio, ;2006;Developmental biology;295;559-70; 16696966

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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