MGI phenotypes (allele matching)
B6;129S7-Del(16T10-Hira)4Bld/Cnrm
| Status | Available to order |
| EMMA ID | EM:02598 |
| Citation information | RRID:IMSR_EM:02598 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129S7-Del(16T10-Hira)4Bld/Cnrm |
| Alternative name | Df(16)4, alias Rv41 |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Del(16T10-Hira)4Bld |
| Gene/Transgene symbol | Del(16T10-Hira)4Bld |
Information from provider
| Provider | Antonio BALDINI |
| Provider affiliation | Institute of Genetics and Biophysics (IGB), National Research Council (CNR) |
| Genetic information | Targeted chromosomal deletion obtained with a Cre-loxP strategy. |
| Phenotypic information | These animals have the haploinsufficiency phenotype of Tbx1+/- animals (low penetrance of cardiovascular defects). |
| Breeding history | Backcrossed into C57BL/6 for 3 generations. Now is sibling crossed. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome.;Paylor Richard, Glaser Beate, Mupo Annalisa, Ataliotis Paris, Spencer Corinne, Sobotka Angela, Sparks Chelsey, Choi Chul-Hee, Oghalai John, Curran Sarah, Murphy Kieran C, Monks Stephen, Williams Nigel, O'Donovan Michael C, Owen Michael J, Scambler Peter J, Lindsay Elizabeth, ;2006;Proceedings of the National Academy of Sciences of the United States of America;103;7729-34; 16684884
- Genetic dissection of the DiGeorge syndrome phenotype.;Vitelli F, Lindsay E A, Baldini A, ;2002;Cold Spring Harbor symposia on quantitative biology;67;327-32; 12858556