MGI phenotypes (allele matching)
B6;129S7-Del(16T10-Hira)4Bld/Cnrm
| Status | Available to order |
| EMMA ID | EM:02598 |
| International strain name | B6;129S7-Del(16T10-Hira)4Bld/Cnrm |
| Alternative name | Df(16)4, alias Rv41 |
| Strain type | Targeted Mutant Strains : Other targeted |
| Allele/Transgene symbol | Del(16T10-Hira)4Bld, |
| Gene/Transgene symbol | Del(16T10-Hira)4Bld |
Information from provider
| Provider | Antonio BALDINI |
| Provider affiliation | Institute of Genetics and Biophysics (IGB), National Research Council (CNR) |
| Genetic information | Targeted chromosomal deletion obtained with a Cre-loxP strategy. |
| Phenotypic information | These animals have the haploinsufficiency phenotype of Tbx1+/- animals (low penetrance of cardiovascular defects). |
| Breeding history | Backcrossed into C57BL/6 for 3 generations. Now is sibling crossed. |
| References |
|
| Homozygous fertile | no |
| Homozygous viable | no |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Tbx1 haploinsufficiency is linked to behavioral disorders in mice and humans: implications for 22q11 deletion syndrome.;Paylor Richard, Glaser Beate, Mupo Annalisa, Ataliotis Paris, Spencer Corinne, Sobotka Angela, Sparks Chelsey, Choi Chul-Hee, Oghalai John, Curran Sarah, Murphy Kieran C, Monks Stephen, Williams Nigel, O'Donovan Michael C, Owen Michael J, Scambler Peter J, Lindsay Elizabeth, ;2006;Proceedings of the National Academy of Sciences of the United States of America;103;7729-34; 16684884
- Genetic dissection of the DiGeorge syndrome phenotype.;Vitelli F, Lindsay E A, Baldini A, ;2002;Cold Spring Harbor symposia on quantitative biology;67;327-32; 12858556