| Status | Available to order |
| EMMA ID | EM:02611 |
| Citation information | RRID:IMSR_EM:02611 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | CnbcLmon:NMRI-Tg(tetO-Tyr)1335Lmon Tg(Tyr-rtTA)4111Lmon |
| Alternative name | TRETyBS/HSTyrTET |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Tyr-rtTA)4111Lmon, Tg(tetO-Tyr)1335Lmon, Tyrc |
| Gene/Transgene symbol | Tg(Tyr-rtTA)4111Lmon, Tg(tetO-Tyr)1335Lmon, Tyr |
| Provider | Lluis Montoliu |
| Provider affiliation | Departamento de Biologia Molecular y Celular, CNB-CSIC, Centro Nacional de Biotecnologia |
| Genetic information | Double transgenic mice carrying two constructs for doxycycline-mediated tyrosinase gene regulation (TET-ON model). Animal mouse model of oculocutaneous albinism type 1 (OCA1). It uses the first Tet system developed by H. Bujard and colleagues, therefore the version used of the transactivator was "Tet On/Off" (Tet On scheme, using rtTA) and the version of the Tet promoter was "PTRE". See PubMed ID:15250938. |
| Phenotypic information | In the off status, externally undistinguishable from a common albino phenotype. Upon doxycycline/tetracycline treatment from first gestational week pups will show a darker ruby eye colour. Coat colour is not modified by doxycycline/tetracycline treatment. |
| Breeding history | Transgenic mice were initially generated in FVB/HanHsd albino inbred mice but expanded in HsdWin:NMRI albino outbred mice to avoid the retinal degeneration mutation (Pdebrd1), carried by the FVB/HanHsd genotype. Mice were bred to double transgenic homozygosity and have been maintained since then as double transgenic homozygous in HsdWin:NMRI albino outbred mice (more than 20 generations). |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | yes |
| Immunocompromised | no |
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous NMRI males, wild-type NMRI females |
| Stage of embryos | 8-cell |
Orphanet associated rare diseases, based on orthologous gene matching
