129/Sv-Vax1tm1Pgr/PgrCnrm

Status

Available to order

EMMA IDEM:00274
International strain name129/Sv-Vax1tm1Pgr/PgrCnrm
Alternative nameVax1
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolVax1tm1Pgr,
Gene/Transgene symbolVax1

Information from provider

ProviderPeter Gruss
Provider affiliationMax Planck Inst. Biophysical Chemistry
Genetic information6.2 kb 5-prime Vax1 genomic fragment, beta galactosidase, 8.5 kb 3-prime Vax1 genomic fragment
Phenotypic informationDefects in basal forebrain and optic nerve development (see Hallonet et al., 1999). Model of optic nerve coloboma.
References
  • Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system.;Hallonet M, Hollemann T, Pieler T, Gruss P, ;1999;Genes & development;13;3106-14; 10601036

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (allele matching)
  • cleft palate / MGI
  • abnormal corpus callosum morphology / MGI
  • abnormal hypothalamus morphology / MGI
  • abnormal telencephalon development / MGI
  • abnormal optic nerve morphology / MGI
  • abnormal optic nerve innervation / MGI
  • premature death / MGI
  • abnormal forebrain development / MGI
  • holoprosencephaly / MGI
  • coloboma / MGI
  • abnormal anterior commissure morphology / MGI
  • absent optic chiasm / MGI
  • lethality at weaning, incomplete penetrance / MGI
  • perinatal lethality, incomplete penetrance / MGI
  • abnormal upper incisor morphology / MGI
  • fused upper incisors / MGI

Literature references

  • Vax1, a novel homeobox-containing gene, directs development of the basal forebrain and visual system.;Hallonet M, Hollemann T, Pieler T, Gruss P, ;1999;Genes & development;13;3106-14; 10601036

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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