- abnormal placenta morphology / MGI
- abnormal allantois morphology / MGI
- small placenta / MGI
- abnormal chorionic plate morphology / MGI
- embryonic lethality during organogenesis, incomplete penetrance / MGI
- decreased placental labyrinth size / MGI
- abnormal placenta intervillous maternal lacunae morphology / MGI
- decreased spongiotrophoblast size / MGI
- mortality/aging / MGI
B6.129-Gjb3tm1Kwi/Cnrm
Status | Available to order |
EMMA ID | EM:00324 |
International strain name | B6.129-Gjb3tm1Kwi/Cnrm |
Alternative name | Cx31 KO (LacZ) |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Gjb3tm1Kwi, |
Gene/Transgene symbol | Gjb3 |
Information from provider
Provider | Klaus WILLECKE |
Provider affiliation | Molekulargenetik, Institut fuer Genetik, Universitaet Bonn |
Genetic information | Exon 2, including the whole open reading frame of Cx31 (Gjb3), is homologously replaced by the lacZ open reading frame and a MCI promotor-controlled neo selection marker gene, which is still in the genome. |
Phenotypic information | Transient placental dysmorphogenesis resulting in reduced offspring. |
Breeding history | After blastocyst injection the chimeras were bred with C57BL/6NCrl to obtain brown coat coloured offspring. This brown offspring was backcrossed to C57BL/6NCrl more than three times. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Breeding at archiving centre | Backcrossed to C57BL/6J |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive non-syndromic sensorineural deafness type DFNB / Orphanet_90636
- Neuropathy with hearing impairment / Orphanet_139512
- Autosomal dominant non-syndromic sensorineural deafness type DFNA / Orphanet_90635
- Erythrokeratodermia variabilis / Orphanet_317
MGI phenotypes (allele matching)
Literature references
- Connexin31-deficiency in mice causes transient placental dysmorphogenesis but does not impair hearing and skin differentiation.;Plum A, Winterhager E, Pesch J, Lautermann J, Hallas G, Rosentreter B, Traub O, Herberhold C, Willecke K, ;2001;Developmental biology;231;334-47; 11237463
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