B6.129-Gjb3tm1Kwi/Cnrm

Status

Available to order

EMMA IDEM:00324
International strain nameB6.129-Gjb3tm1Kwi/Cnrm
Alternative nameCx31 KO (LacZ)
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolGjb3tm1Kwi,
Gene/Transgene symbolGjb3

Information from provider

ProviderKlaus WILLECKE
Provider affiliationMolekulargenetik, Institut fuer Genetik, Universitaet Bonn
Genetic informationExon 2, including the whole open reading frame of Cx31 (Gjb3), is homologously replaced by the lacZ open reading frame and a MCI promotor-controlled neo selection marker gene, which is still in the genome.
Phenotypic informationTransient placental dysmorphogenesis resulting in reduced offspring.
Breeding historyAfter blastocyst injection the chimeras were bred with C57BL/6NCrl to obtain brown coat coloured offspring. This brown offspring was backcrossed to C57BL/6NCrl more than three times.
References
  • Connexin31-deficiency in mice causes transient placental dysmorphogenesis but does not impair hearing and skin differentiation.;Plum A, Winterhager E, Pesch J, Lautermann J, Hallas G, Rosentreter B, Traub O, Herberhold C, Willecke K, ;2001;Developmental biology;231;334-47; 11237463

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy
Breeding at archiving centreBackcrossed to C57BL/6J

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal placenta morphology / MGI
  • abnormal allantois morphology / MGI
  • small placenta / MGI
  • abnormal chorionic plate morphology / MGI
  • embryonic lethality during organogenesis, incomplete penetrance / MGI
  • decreased placental labyrinth size / MGI
  • abnormal placenta intervillous maternal lacunae morphology / MGI
  • decreased spongiotrophoblast size / MGI
  • mortality/aging / MGI

Literature references

  • Connexin31-deficiency in mice causes transient placental dysmorphogenesis but does not impair hearing and skin differentiation.;Plum A, Winterhager E, Pesch J, Lautermann J, Hallas G, Rosentreter B, Traub O, Herberhold C, Willecke K, ;2001;Developmental biology;231;334-47; 11237463

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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