B6.129P2-Gjd2tm1Kwi/Cnrm

Status

Available to order

EMMA IDEM:00326
International strain nameB6.129P2-Gjd2tm1Kwi/Cnrm
Alternative nameCx36 KO
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolGjd2tm1Kwi,
Gene/Transgene symbolGjd2

Information from provider

ProviderKlaus WILLECKE
Provider affiliationMolekulargenetik, Institut fuer Genetik, Universitaet Bonn
Genetic informationExon 2, including most of the open reading frame of Cx36 (Gjd2), is homologously replaced by a two loxP sites-flanked selection marker gene (HPRT), which is still in the genome.
Phenotypic informationVisual transmission defect.
Breeding historyAfter blastocyst injection the chimeras were bred with C57BL/6NCrl to obtain brown coat coloured offspring. This brown offspring was backcrossed to C57BL/6NCrl more than three times.
References
  • Visual transmission deficits in mice with targeted disruption of the gap junction gene connexin36.;Güldenagel M, Ammermüller J, Feigenspan A, Teubner B, Degen J, Söhl G, Willecke K, Weiler R, ;2001;The Journal of neuroscience : the official journal of the Society for Neuroscience;21;6036-44; 11487627

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy
Breeding at archiving centreBackcrossed to C57BL/6J

Disease and phenotype information

MGI phenotypes (allele matching)
  • abnormal nervous system electrophysiology / MGI
  • decreased insulin secretion / MGI
  • abnormal retinal ganglion layer morphology / MGI
  • digestive/alimentary phenotype / MGI
  • abnormal cued conditioning behavior / MGI
  • abnormal single cell response / MGI
  • abnormal nerve fiber response / MGI
  • abnormal pancreatic beta cell physiology / MGI
  • abnormal insulin secretion / MGI
  • behavior/neurological phenotype / MGI

Literature references

  • Visual transmission deficits in mice with targeted disruption of the gap junction gene connexin36.;Güldenagel M, Ammermüller J, Feigenspan A, Teubner B, Degen J, Söhl G, Willecke K, Weiler R, ;2001;The Journal of neuroscience : the official journal of the Society for Neuroscience;21;6036-44; 11487627

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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