B6.129P2-Gja1tm2(Gjb1)Kwi/Cnrm

Status

Available to order

EMMA IDEM:00328
International strain nameB6.129P2-Gja1tm2(Gjb1)Kwi/Cnrm
Alternative nameCx43-KI-Cx32
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolGja1tm2(Gjb1)Kwi,
Gene/Transgene symbolGja1

Information from provider

ProviderKlaus WILLECKE
Provider affiliationMolekulargenetik, Institut fuer Genetik, Universitaet Bonn
Genetic informationExon 2, including the whole open reading frame of Cx43 (Gja1), is homologously replaced by the coding region of Cx32 (Gjb1); no selection marker gene is maintained in the genome.
Phenotypic informationHeterozygous females have lactation difficulties.
Breeding historyAfter blastocyst injection the chimeras were bred with C57BL/6NCrl to obtain brown coat colored offspring. This brown offspring was backcrossed to C57BL/6NCrl more than three times.
References
  • Unique and shared functions of different connexins in mice.;Plum A, Hallas G, Magin T, Dombrowski F, Hagendorff A, Schumacher B, Wolpert C, Kim J, Lamers W H, Evert M, Meda P, Traub O, Willecke K, ;2000;Current biology : CB;10;1083-91; 10996788

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy
Breeding at archiving centreBackcrossed to C57BL/6J

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • maternal effect / MGI
  • abnormal milk ejection / MGI
  • abnormal mammary gland alveolus morphology / MGI
  • ventricular premature beat / MGI
  • abnormal mammary gland luminal epithelium morphology / MGI
  • thin ventricular wall / MGI
  • abnormal ovarian follicle morphology / MGI
  • decreased body weight / MGI
  • cataract / MGI
  • irregular heartbeat / MGI
  • reduced female fertility / MGI
  • male infertility / MGI
  • abnormal seminiferous tubule morphology / MGI
  • oligozoospermia / MGI
  • decreased ovulation rate / MGI
  • abnormal heart right ventricle morphology / MGI
  • abnormal trabecula carnea morphology / MGI
  • decreased testis weight / MGI
  • abnormal heart ventricle morphology / MGI
  • ventricular tachycardia / MGI
  • postnatal lethality, incomplete penetrance / MGI

Literature references

  • Unique and shared functions of different connexins in mice.;Plum A, Hallas G, Magin T, Dombrowski F, Hagendorff A, Schumacher B, Wolpert C, Kim J, Lamers W H, Evert M, Meda P, Traub O, Willecke K, ;2000;Current biology : CB;10;1083-91; 10996788

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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