B6;CBA-Tg(Acta2-AOC3)#Ubc/Kctt
| Status | Available to order |
| EMMA ID | EM:00396 |
| Citation information | RRID:IMSR_EM:00396 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;CBA-Tg(Acta2-AOC3)#Ubc/Kctt |
| Alternative name | SMP8-SSAO |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Acta2-AOC3)#Ubc |
| Gene/Transgene symbol | Tg(Acta2-AOC3)#Ubc |
Information from provider
| Provider | Karin Forsberg-Nilsson |
| Provider affiliation | Department of Medical Biochemistry and Microbiology, Department of Medical Biochemistry and Microbiology |
| Genetic information | Transgenic model for the overexpression of human amine oxidase, copper containing 3 (AOC3; also called SSAO, semicarbazide-sensitive amine oxidase) in mice. A smooth muscle-specific promoter, the MP8 promoter fragment from the mouse actin-alpha 2 (Acta2) gene, was used. Transgenic expression of human SSAO in tissues with a high content of smooth muscle cells was confirmed by Northern blot analysis. |
| Phenotypic information | Histopathological evaluation of aorta and renal artery from transgenic mice revealed an abnormal structure of the elastin tissue. Instead of the regularly folded elastic laminaes normally found in tunica media of sacrificed mice, the elastic laminaes were straight and unfolded with irregularly arranged elastic fibers, forming tangled webs, between the intercalating elastic laminaes. These alterations of the elastin structures suggest that overexpression of SSAO has led to a reduced elasticity of the arteries. Moreover, the mean femoral arterial pressure of the SMP8 SSAO transgenic mice was significantly lower in comparison to non-transgenic littermates. This suggests that the transgenic mice have a defect in their ability to regulate blood pressure. |
| References |
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Information from EMMA
| Archiving centre | Karolinska Institutet, Stockholm, Sweden |
Literature references
- Overexpression of semicarbazide-sensitive amine oxidase in smooth muscle cells leads to an abnormal structure of the aortic elastic laminas.;Göktürk Camilla, Nilsson Joakim, Nordquist Jenny, Kristensson Millvej, Svensson Kristian, Söderberg Charlotte, Israelson Marianne, Garpenstrand Håkan, Sjöquist Mats, Oreland Lars, Forsberg-Nilsson Karin, ;2003;The American journal of pathology;163;1921-8; 14578191
- Studies on semicarbazide-sensitive amine oxidase in patients with diabetes mellitus and in transgenic mice.;Göktürk C, Garpenstrand H, Nilsson J, Nordquist J, Oreland L, Forsberg-Nilsson K, ;2003;Biochimica et biophysica acta;1647;88-91; 12686114