B6D2-Tg(PySTdeltaMT)82Poz/Cnrm
| Status | Available to order |
| EMMA ID | EM:00401 |
| International strain name | B6D2-Tg(PySTdeltaMT)82Poz/Cnrm |
| Alternative name | TG Py AS Fo82 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(PySTdeltaMT)82Poz, |
| Gene/Transgene symbol | Tg(PySTdeltaMT)82Poz |
Information from provider
| Provider | Laura POZZI |
| Provider affiliation | Centro Ricerca Sperimentale - Istituto Regina Elena |
| Genetic information | See publication: Felici A et al. Medullary thyroid carcinoma in transgenic mice expressing a Polyoma carboxyl-terminal truncated middle-T and wild-type small-T antigens. Oncogene 18, 2387-2395, 1999. |
| Phenotypic information | medullary thyroid carcinoma (tumor onset: 3-4 months), lethal by month 5-7 (full penetrance); - wavy hair and whiskers (full penetrance); - mild eye cataract, onset by week 4-5 (about 80% penetrance). |
| Breeding history | Heterozygous males (genotyped by coat phenotype or the presence of cataract) are mated with wild-type B6DF1 females. Females are usually discarded from litters early after birth, since they are not used for transgene transmission. It is preferable to maintain the transgene in heterozygotes since homozygotes develop the tumor faster and die earlier. Life span of heterozygotes is usually 6-8 months. |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Medullary thyroid carcinomas in transgenic mice expressing a Polyoma carboxyl-terminal truncated middle-T and wild type small-T antigens.;Felici A, Giorgio M, Krauzewicz N, Della Rocca C, Santoro M, Rovere P, Manni I, Amati P, Pozzi L, ;1999;Oncogene;18;2387-95; 10327060