FVB;129P2-Pten^tm1Mro/Cnrm

Status	Available to order
EMMA ID	EM:00406
International strain name	FVB;129P2-Pten^tm1Mro/Cnrm
Alternative name	PtnF
Strain type	Targeted Mutant Strains : Conditional mutation
Allele/Transgene symbol	Pten^tm1Mro,
Gene/Transgene symbol	Pten

Information from provider

Provider	Anton Berns
Provider affiliation	Research - Animal Facility, The Netherlands Cancer Institute
Genetic information	A 9 kb fragment containing a neomycin selection cassette flanked by loxP sites and a loxP sequence placed 1.3 kb downstream of exon 5 of the Pten gene, was electroporated into ES cells (129 origin), resulting in the insertion of loxP sites into the fourth and the fifth intron, flanking exon 5.
Phenotypic information	Conditional Pten knock-out, no phenotype.
References	PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum.;Marino Silvia, Krimpenfort Paul, Leung Carly, van der Korput Hetty A G M, Trapman Jan, Camenisch Isabelle, Berns Anton, Brandner Sebastian, ;2002;Development (Cambridge, England);129;3513-22; 12091320

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

Squamous cell carcinoma of salivary glands / Orphanet_500481
Squamous cell carcinoma of the oral cavity / Orphanet_502363
Squamous cell carcinoma of the larynx / Orphanet_494550
Squamous cell carcinoma of the oropharynx / Orphanet_500478
Squamous cell carcinoma of the nasal cavity and paranasal sinuses / Orphanet_500464
Squamous cell carcinoma of the hypopharynx / Orphanet_494547
Squamous cell carcinoma of the lip / Orphanet_502366
Activated PI3K-delta syndrome / Orphanet_397596
Lhermitte-Duclos disease / Orphanet_65285
Cowden syndrome / Orphanet_201
Bannayan-Riley-Ruvalcaba syndrome / Orphanet_109
Macrocephaly-intellectual disability-autism syndrome / Orphanet_210548
Proteus-like syndrome / Orphanet_2969
Segmental outgrowth-lipomatosis-arteriovenous malformation-epidermal nevus syndrome / Orphanet_137608
Proteus syndrome / Orphanet_744
Bilateral frontoparietal polymicrogyria / Orphanet_101070

Literature references

PTEN is essential for cell migration but not for fate determination and tumourigenesis in the cerebellum.;Marino Silvia, Krimpenfort Paul, Leung Carly, van der Korput Hetty A G M, Trapman Jan, Camenisch Isabelle, Berns Anton, Brandner Sebastian, ;2002;Development (Cambridge, England);129;3513-22; 12091320

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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FVB;129P2-Ptentm1Mro/Cnrm