FVB;129P2-Cdkn2atm2Brn/Cnrm
| Status | Available to order |
| EMMA ID | EM:00407 |
| International strain name | FVB;129P2-Cdkn2atm2Brn/Cnrm |
| Alternative name | I4aF |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Cdkn2atm2Brn, |
| Gene/Transgene symbol | Cdkn2a |
Information from provider
| Provider | Anton Berns |
| Provider affiliation | Research - Animal Facility, The Netherlands Cancer Institute |
| Genetic information | Exons 2 and 3 are flanked by loxP sites. |
| Phenotypic information | Conditional p16ink4a and p19Arf knock-out, no phenotype |
| References |
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Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice.;Krimpenfort P, Quon K C, Mooi W J, Loonstra A, Berns A, ;2001;Nature;413;83-6; 11544530
- A Versatile ES Cell-Based Melanoma Mouse Modeling Platform.;Bok Ilah, Vera Olga, Xu Xiaonan, Jasani Neel, Nakamura Koji, Reff Jordan, Nenci Arianna, Gonzalez Jose G, Karreth Florian A, ;2020;Cancer research;80;912-921; 31744817