FVB.Cg-Tg(IghMyc)186Brn/Cnrm

Status	Available to order
EMMA ID	EM:00412
International strain name	FVB.Cg-Tg(IghMyc)186Brn/Cnrm
Alternative name	Emyc
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(IghMyc)186Brn,
Gene/Transgene symbol	Tg(IghMyc)186Brn

Information from provider

Provider	Anton Berns
Provider affiliation	Research - Animal Facility, The Netherlands Cancer Institute
Genetic information	Zygote injection of transgene: c-myc (myelocytomatosis oncogene) cDNA under control of the lymphoid-specific immunoglobulin heavy chain enhancer (E-mu).
Phenotypic information	Predisposition to B cell lymphomagenesis, latency 3-12 months. Due to the early onset, mice should be kept as heterozygotes.
Breeding history	The trangene was injected into B6CBA F2 zygotes and was maintained on either B6CBA F1 and/or FVB/N for several years. Mice are now maintained on FVB/N for at least N=3.
References	Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally.;Verbeek S, van Lohuizen M, van der Valk M, Domen J, Kraal G, Berns A, ;1991;Molecular and cellular biology;11;1176-9; 1990273

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Literature references

Mice bearing the E mu-myc and E mu-pim-1 transgenes develop pre-B-cell leukemia prenatally.;Verbeek S, van Lohuizen M, van der Valk M, Domen J, Kraal G, Berns A, ;1991;Molecular and cellular biology;11;1176-9; 1990273

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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