FVB;129P2-Trp53^tm1Brn/Cnrm

Status	Available to order
EMMA ID	EM:00432
International strain name	FVB;129P2-Trp53^tm1Brn/Cnrm
Alternative name	P53F
Strain type	Targeted Mutant Strains : Conditional mutation
Allele/Transgene symbol	Trp53^tm1Brn,
Gene/Transgene symbol	Trp53

Information from provider

Provider	Anton Berns
Provider affiliation	Research - Animal Facility, The Netherlands Cancer Institute
Genetic information	Insertion of loxP sequences 5' of exon 2 and 3' of exon 10 of the Trp53 gene.
Phenotypic information	P53F conditional knock-out mice do not reveal any phenotype.
References	Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum.;Marino S, Vooijs M, van Der Gulden H, Jonkers J, Berns A, ;2000;Genes & development;14;994-1004; 10783170 Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.;Jonkers J, Meuwissen R, van der Gulden H, Peterse H, van der Valk M, Berns A, ;2001;Nature genetics;29;418-25; 11694875

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Literature references

Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum.;Marino S, Vooijs M, van Der Gulden H, Jonkers J, Berns A, ;2000;Genes & development;14;994-1004; 10783170
Synergistic tumor suppressor activity of BRCA2 and p53 in a conditional mouse model for breast cancer.;Jonkers J, Meuwissen R, van der Gulden H, Peterse H, van der Valk M, Berns A, ;2001;Nature genetics;29;418-25; 11694875

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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FVB;129P2-Trp53tm1Brn/Cnrm