FVB;129P2-Rb1tm2Brn/Cnrm
| Status | Available to order |
| EMMA ID | EM:00433 |
| International strain name | FVB;129P2-Rb1tm2Brn/Cnrm |
| Alternative name | RbF |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Rb1tm2Brn, |
| Gene/Transgene symbol | Rb1 |
Information from provider
| Provider | Anton Berns |
| Provider affiliation | Research - Animal Facility, The Netherlands Cancer Institute |
| Genetic information | Insertion of loxP sequences into the introns surrounding exon 19 of the Rb1 gene. |
| Phenotypic information | Conditional Rb1 knock-out; no phenotype. |
| References |
|
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Small cell lung cancer / Orphanet_70573
- Non-hereditary retinoblastoma / Orphanet_357034
- Hereditary retinoblastoma / Orphanet_357027
Literature references
- Induction of medulloblastomas in p53-null mutant mice by somatic inactivation of Rb in the external granular layer cells of the cerebellum.;Marino S, Vooijs M, van Der Gulden H, Jonkers J, Berns A, ;2000;Genes & development;14;994-1004; 10783170