FVB;129P2-Rb1tm1Brn/Cnrm
| Status | Available to order |
| EMMA ID | EM:00434 |
| International strain name | FVB;129P2-Rb1tm1Brn/Cnrm |
| Alternative name | RbFR |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Rb1tm1Brn, |
| Gene/Transgene symbol | Rb1 |
Information from provider
| Provider | Anton Berns |
| Provider affiliation | Research - Animal Facility, The Netherlands Cancer Institute |
| Genetic information | Two frt sequences were inserted into the introns surrounding exon 19 of the Rb1 gene. Using a two step hit-and-run gene targeting strategy these frt sites were introduced into the mouse genome. An Hprt resistance gene was included that allowed both positive and negative selection in the HM-1, Hprt-deficient ES cell line. |
| Phenotypic information | Conditional Rb1 (RbFR) mutant; no phenotype. |
| References |
|
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Small cell lung cancer / Orphanet_70573
- Non-hereditary retinoblastoma / Orphanet_357034
- Hereditary retinoblastoma / Orphanet_357027
Literature references
- Flp-mediated tissue-specific inactivation of the retinoblastoma tumor suppressor gene in the mouse.;Vooijs M, van der Valk M, te Riele H, Berns A, ;1998;Oncogene;17;1-12; 9671308