129-Mta1^{tm1a(EUCOMM)Wtsi}/WtsiH

Status	Available to order
EMMA ID	EM:04341
Citation information	RRID:IMSR_EM:04341 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	129-Mta1^{tm1a(EUCOMM)Wtsi}/WtsiH
Alternative name	EPD0002_2_B07
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Mta1^{tm1a(EUCOMM)Wtsi}
Gene/Transgene symbol	Mta1
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from EUCOMM ES clone EPD0002_2_B07. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Information from EMMA

Archiving centre	Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (allele matching)

abnormal rib morphology / IMPC
decreased circulating LDL cholesterol level / IMPC
decreased body weight / IMPC
trunk curl / IMPC
decreased caudal vertebrae number / IMPC
increased thermal nociceptive threshold / IMPC
abnormal skin morphology / IMPC
abnormal skin pigmentation / IMPC
abnormal tail morphology / IMPC
decreased mean corpuscular volume / IMPC
abnormal bone mineralization / IMPC
increased lean body mass / IMPC
decreased lumbar vertebrae number / IMPC
decreased sacral vertebrae number / IMPC
abnormal behavior / IMPC
absent pinna reflex / IMPC

IMPC phenotypes (gene matching)

increased thermal nociceptive threshold / IMPC
abnormal skin morphology / IMPC
abnormal skin pigmentation / IMPC
abnormal tail morphology / IMPC
decreased lumbar vertebrae number / IMPC
abnormal behavior / IMPC
decreased sacral vertebrae number / IMPC
decreased mean corpuscular volume / IMPC
absent pinna reflex / IMPC
decreased caudal vertebrae number / IMPC
abnormal rib morphology / IMPC
abnormal bone mineralization / IMPC
decreased body weight / IMPC
decreased circulating LDL cholesterol level / IMPC
increased lean body mass / IMPC
trunk curl / IMPC

MGI phenotypes (allele matching)

decreased caudal vertebrae number / MGI
increased circulating triglyceride level / MGI
decreased circulating LDL cholesterol level / MGI
abnormal bone mineralization / MGI
thrombocytopenia / MGI
decreased lumbar vertebrae number / MGI
abnormal behavior / MGI
increased sacral vertebrae number / MGI

MGI phenotypes (gene matching)

decreased circulating LDL cholesterol level / MGI
decreased caudal vertebrae number / MGI
increased circulating triglyceride level / MGI
abnormal bone mineralization / MGI
thrombocytopenia / MGI
increased cellular sensitivity to ionizing radiation / MGI
decreased lumbar vertebrae number / MGI
abnormal behavior / MGI
vision/eye phenotype / MGI
abnormal retinal development / MGI
increased sacral vertebrae number / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*
LacZ tagged null allele (tm1b allele), service fee and delivery time available upon request
Conditional ready allele (tm1c allele), service fee and delivery time available upon request
Reporterless null allele (tm1d allele), service fee and delivery time available upon request
Tissue - Types of tissue, service fee and delivery time available upon request

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
MTA will be issued after an order has been submitted.

EMMA conditions
Legally binding conditions for the transfer

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129-Mta1tm1a(EUCOMM)Wtsi/WtsiH