FVB;129P2-Cdkn2atm1.1Brn/Cnrm
Status | Available to order |
EMMA ID | EM:00435 |
International strain name | FVB;129P2-Cdkn2atm1.1Brn/Cnrm |
Alternative name | P16B |
Strain type | Targeted Mutant Strains : Other targeted |
Allele/Transgene symbol | Cdkn2atm1.1Brn, |
Gene/Transgene symbol | Cdkn2a |
Information from provider
Provider | Anton Berns |
Provider affiliation | Research - Animal Facility, The Netherlands Cancer Institute |
Genetic information | Point mutation in exon 2 (p16Ink4a open reading frame) of Cdkn2a gene; hom. rec. in ES cells |
Phenotypic information | p16Ink4a-specific mutant with expression of functional p19Arf; shows no obvious phenotype |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Loss of p16Ink4a confers susceptibility to metastatic melanoma in mice.;Krimpenfort P, Quon K C, Mooi W J, Loonstra A, Berns A, ;2001;Nature;413;83-6; 11544530
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