B6.129P2(FVB)-Fgf3tm1Sng/Cnbc
Status | Available to order |
EMMA ID | EM:04387 |
International strain name | B6.129P2(FVB)-Fgf3tm1Sng/Cnbc |
Alternative name | Fgf3ko |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Fgf3tm1Sng, |
Gene/Transgene symbol | Fgf3 |
Information from provider
Provider | Thomas Schimmang |
Provider affiliation | IBGM |
Genetic information | Targeting construct from 129. The coding region of Fgf3 is deleted. |
Phenotypic information | Homozygous mutants are viable and fertile. Tail defect with 100% penetrance. Inner ear defect with variable penetrance and expressivity. |
Breeding history | Backcrossed on C57BL/6 for 10 generations. |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
Animals used for archiving | homozygous C57BL/6J, wild-type C57BL/6J |
Stage of embryos | 8-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Deafness with labyrinthine aplasia, microtia, and microdontia / Orphanet_90024
MGI phenotypes (allele matching)
Literature references
- Requirements for FGF3 and FGF10 during inner ear formation.;Alvarez Yolanda, Alonso Maria Teresa, Vendrell Victor, Zelarayan Laura Cecilia, Chamero Pablo, Theil Thomas, Bösl Michael R, Kato Shigeaki, Maconochie Mark, Riethmacher Dieter, Schimmang Thomas, ;2003;Development (Cambridge, England);130;6329-38; 14623822
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