B6Dnk;B6N-Ercc2tm1a(EUCOMM)Wtsi/H

Status

Available to order

EMMA IDEM:04416
Citation informationRRID:IMSR_EM:04416 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6Dnk;B6N-Ercc2tm1a(EUCOMM)Wtsi/H
Alternative nameEPD0105_4_A10
Strain typeTargeted Mutant Strains
Allele/Transgene symbolErcc2tm1a(EUCOMM)Wtsi
Gene/Transgene symbolErcc2
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0105_4_A10. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom
Animals used for archivingheterozygous C57BL/6Dnk males
Breeding at archiving centreChimeras were mated to C57BL/6Dnk and maintained on this background thereafter.

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)
  • preweaning lethality, complete penetrance / IMPC
IMPC phenotypes (gene matching)
  • preweaning lethality, complete penetrance / IMPC
MGI phenotypes (gene matching)
  • decreased bone mineral density / MGI
  • osteoporosis / MGI
  • kyphosis / MGI
  • decreased hematocrit / MGI
  • abnormal coat/ hair morphology / MGI
  • abnormal hair follicle morphology / MGI
  • enlarged hair follicles / MGI
  • alopecia / MGI
  • sparse hair / MGI
  • abnormal sebaceous gland morphology / MGI
  • enlarged sebaceous gland / MGI
  • enlarged spleen / MGI
  • tremors / MGI
  • abnormal testis morphology / MGI
  • reddish skin / MGI
  • scaly skin / MGI
  • thick skin / MGI
  • skin photosensitivity / MGI
  • abnormal epidermis stratum granulosum morphology / MGI
  • hyperkeratosis / MGI
  • decreased body size / MGI
  • microphthalmia / MGI
  • abnormal lens morphology / MGI
  • cataract / MGI
  • small lens / MGI
  • corneal opacity / MGI
  • decreased exploration in new environment / MGI
  • limb grasping / MGI
  • anemia / MGI
  • abnormal hemoglobin / MGI
  • postnatal growth retardation / MGI
  • acanthosis / MGI
  • reduced female fertility / MGI
  • female infertility / MGI
  • abnormal ovulation / MGI
  • neoplasm / MGI
  • increased incidence of induced tumors / MGI
  • premature death / MGI
  • disproportionate dwarf / MGI
  • decreased hemoglobin content / MGI
  • decreased erythrocyte cell number / MGI
  • white spotting / MGI
  • astrocytosis / MGI
  • nervous system phenotype / MGI
  • premature aging / MGI
  • abnormal hair cuticle / MGI
  • brittle hair / MGI
  • greasy coat / MGI
  • increased incidence of tumors by chemical induction / MGI
  • increased incidence of tumors by UV-induction / MGI
  • cachexia / MGI
  • abnormal circulating amino acid level / MGI
  • growth/size/body region phenotype / MGI
  • immune system phenotype / MGI
  • reproductive system phenotype / MGI
  • skeleton phenotype / MGI
  • hematopoietic system phenotype / MGI
  • abnormal skeleton morphology / MGI
  • abnormal cell physiology / MGI
  • abnormal DNA repair / MGI
  • increased cellular sensitivity to ultraviolet irradiation / MGI
  • decreased cellular sensitivity to ultraviolet irradiation / MGI
  • microgliosis / MGI
  • abnormal fat cell morphology / MGI
  • decreased total body fat amount / MGI
  • rough coat / MGI
  • focal dorsal hair loss / MGI
  • nuclear cataracts / MGI
  • increased skin tumor incidence / MGI
  • decreased tumor latency / MGI
  • mortality/aging / MGI
  • integument phenotype / MGI
  • embryonic lethality before implantation, complete penetrance / MGI
  • vacuolated lens / MGI
  • abnormal response to radiation / MGI

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