- abnormal dendritic cell antigen presentation / MGI
- abnormal antigen presentation / MGI
- abnormal level of surface class II molecules / MGI
- decreased CD4-positive, alpha beta T cell number / MGI
- increased CD8-positive, alpha-beta T cell number / MGI
- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- abnormal B cell physiology / MGI
- abnormal T cell number / MGI
- decreased susceptibility to bacterial infection / MGI
- decreased CD8-positive, alpha-beta T cell number / MGI
- increased T-helper 1 cell number / MGI
- decreased susceptibility to bacterial infection induced morbidity/mortality / MGI
- abnormal antigen presentation via MHC class I / MGI
- defective assembly of class I molecules / MGI
- defective intracellular transport of class I molecules / MGI
- decreased level of surface class I molecules / MGI
- decreased cytotoxic T cell cytolysis / MGI
- absent CD8-positive, alpha-beta T cells / MGI
- abnormal lymphocyte physiology / MGI
- decreased double-negative T cell number / MGI
- abnormal T cell physiology / MGI
- decreased susceptibility to autoimmune diabetes / MGI
- immune system phenotype / MGI
- increased activated T cell number / MGI
- rectal prolapse / MGI
- abnormal colon morphology / MGI
- abnormal intestinal mucosa morphology / MGI
- enlarged spleen / MGI
- spleen hyperplasia / MGI
- colitis / MGI
- increased T cell number / MGI
- diarrhea / MGI
- decreased T cell proliferation / MGI
- increased gamma-delta T cell number / MGI
- enlarged mesenteric lymph nodes / MGI
- abnormal neuron proliferation / MGI
- abnormal thymus cortex morphology / MGI
- increased immunoglobulin level / MGI
- increased IgE level / MGI
- abnormal immune system organ morphology / MGI
- increased autoantibody level / MGI
- increased anti-double stranded DNA antibody level / MGI
- increased anti-nuclear antigen antibody level / MGI
- increased B cell number / MGI
- abnormal T cell morphology / MGI
- small Peyer's patches / MGI
- increased IgG1 level / MGI
- abnormal splenic cell ratio / MGI
- absent thymus medulla / MGI
- enlarged thymus cortex / MGI
- abnormal kidney morphology / MGI
- increased urine protein level / MGI
STOCK Mr1tm1Gfn Tcratm1Mjo Tap1tm1Arp Cd74tm1Doi Tg(Tcra-V19-J33)#Lantz Tg(Tcrb-V6)#Lantz/Orl
Status | Available to order |
EMMA ID | EM:04509 |
International strain name | STOCK Mr1tm1Gfn Tcratm1Mjo Tap1tm1Arp Cd74tm1Doi Tg(Tcra-V19-J33)#Lantz Tg(Tcrb-V6)#Lantz/Orl |
Alternative name | iVa19/Vb6 Calpha ko TAP-/- ii -/- MR1+/- |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Mr1tm1Gfn, |
Gene/Transgene symbol | Mr1 |
Information from provider
Provider | Olivier Lantz |
Provider affiliation | immunology, Institut Curie |
Genetic information | The VJ alpha (Va19-Ja33) and beta (Vb6) of MAIT cell hybridoma have been inserted into the shuttle vector described by Patten et al (J Immunol. 1993 Mar 15;150(6):2281-94.). The Va19-Ja33 transgene was introduced into B6 x DBA/2 eggs before being backcrossed 10 times to C57BL/6J. The Vb6 transgene was injected into C57BL/6 eggs. |
Phenotypic information | The strain expresses a monoclonal population of MAIT cells. |
Breeding history | It is a double transgenic (independently injected and thus not linked). It is immunodeficient and requires homozygous breeding. |
References |
|
Homozygous fertile | yes |
Homozygous viable | yes |
Homozygous matings required | yes |
Immunocompromised | yes |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Breeding at archiving centre | Males transgenic for Tg(Tcra-V19-J33)#Lantz (iVa) and Tg(Tcrb-V6)#Lantz (Vb6), homozygous knock-out for Tap1, Cd74 (ii) and Tcra (C alpha), homozygous or heterozygous knock-out for Mr1. For cryoarchiving females and males were crossed together. |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Immunodeficiency by defective expression of MHC class I / Orphanet_34592
MGI phenotypes (allele matching)
Literature references
- Stepwise development of MAIT cells in mouse and human.;Martin Emmanuel, Treiner Emmanuel, Duban Livine, Guerri Lucia, Laude Hélène, Toly Cécile, Premel Virginie, Devys Anne, Moura Ivan C, Tilloy Florence, Cherif Stéphane, Vera Gabriella, Latour Sylvain, Soudais Claire, Lantz Olivier, ;2009;PLoS biology;7;e54; 19278296
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