IMPC phenotypes (gene matching)
B6;129-Nod2tm1.1Kuv/Orl
| Status | Available to order |
| EMMA ID | EM:04542 |
| Citation information | RRID:IMSR_EM:04542 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129-Nod2tm1.1Kuv/Orl |
| Alternative name | B6.129Sv-Nod2tm1 |
| Strain type | Targeted Mutant Strains : Conditional mutation |
| Allele/Transgene symbol | Nod2tm1.1Kuv |
| Gene/Transgene symbol | Nod2 |
Information from provider
| Provider | Philip ROSENSTIEL |
| Provider affiliation | IKMB, University of Kiel |
| Genetic information | Details available upon request. |
| Phenotypic information | Not known. |
| Breeding history | Backcrossed to C57BL/6 for less than 5 generations. |
| References | None available |
| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | not known |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6J males, wild-type C57BL/6J females |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Blau syndrome / Orphanet_90340
MGI phenotypes (gene matching)
- increased leukocyte cell number / MGI
- increased neutrophil cell number / MGI
- abnormal immune system morphology / MGI
- abnormal Peyer's patch morphology / MGI
- weight loss / MGI
- abnormal immune system physiology / MGI
- altered susceptibility to infection / MGI
- impaired macrophage phagocytosis / MGI
- decreased IgG level / MGI
- abnormal lymph node B cell domain morphology / MGI
- abnormal macrophage morphology / MGI
- abnormal macrophage physiology / MGI
- impaired neutrophil phagocytosis / MGI
- abnormal cytokine secretion / MGI
- decreased susceptibility to induced arthritis / MGI
- abnormal response to infection / MGI
- increased double-negative T cell number / MGI
- abnormal T-helper 1 physiology / MGI
- increased CD4-positive, alpha beta T cell number / MGI
- increased Peyer's patch number / MGI
- enlarged Peyer's patches / MGI
- abnormal autophagy / MGI
- increased susceptibility to induced colitis / MGI
- increased circulating tumor necrosis factor level / MGI
- decreased tumor necrosis factor secretion / MGI
- increased circulating interferon-gamma level / MGI
- increased circulating interleukin-2 level / MGI
- increased interleukin-1 beta secretion / MGI
- decreased interleukin-6 secretion / MGI
- abnormal cytokine level / MGI
- decreased susceptibility to endotoxin shock / MGI
- abnormal interferon level / MGI
- abnormal interleukin level / MGI
- abnormal tumor necrosis factor level / MGI
- increased sensitivity to xenobiotic induced morbidity/mortality / MGI
- increased susceptibility to bacterial infection induced morbidity/mortality / MGI