B6.Cg-Tg(tetO-Creb*)95Brco/Cnbc

Status	Available to order
EMMA ID	EM:04665
Citation information	RRID:IMSR_EM:04665 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6.Cg-Tg(tetO-Creb*)95Brco/Cnbc
Alternative name	tetO-ACREB95
Strain type	Transgenic Strains
Allele/Transgene symbol	Tg(tetO-Creb*)95Brco
Gene/Transgene symbol	Tg(tetO-Creb*)95Brco

Information from provider

Provider	Angel Barco
Provider affiliation	Servicio de Experimentación Animal, Instituto de Neurociencias de Alicante
Genetic information	Tetracycline regulated expression of the CREB inhibitor, A-CREB. Transgene intended to be used in bitransgenic lines after crossing with tTA or rtTA expressing mice.
Phenotypic information	After crossing with CamKIIa-tTA the bitransgenic line showed striatal specific expression. Altered neuronal physiology, neurodegeneration, abnormal behavior and altered hippocampal gene expression are described in Cereb Cortex. 2009 Nov;19(11):2535-47.
Breeding history	Backcrossed to C57BL/6J for more than 20 generations.
References	Inhibition of cAMP response element-binding protein reduces neuronal excitability and plasticity, and triggers neurodegeneration.;Jancic Dragana, Lopez de Armentia Mikel, Valor Luis M, Olivares Roman, Barco Angel, ;2009;Cerebral cortex (New York, N.Y. : 1991);19;2535-47; 19213815
Homozygous fertile	not known
Homozygous viable	not known
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archiving	heterozygous C57BL/6J males, wild-type C57BL/6J females
Stage of embryos	8-cell

Literature references

Inhibition of cAMP response element-binding protein reduces neuronal excitability and plasticity, and triggers neurodegeneration.;Jancic Dragana, Lopez de Armentia Mikel, Valor Luis M, Olivares Roman, Barco Angel, ;2009;Cerebral cortex (New York, N.Y. : 1991);19;2535-47; 19213815

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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