MGI phenotypes (allele matching)
- decreased fibroblast cell migration / MGI
B6.129-Mrc2tm1Cmi/H
| Status | Available to order |
| EMMA ID | EM:04674 |
| Citation information | RRID:IMSR_EM:04674 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Mrc2tm1Cmi/H |
| Alternative name | Endo180ΔEx2-6/Endo180ΔEx2-6: C57BL/6 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Mrc2tm1Cmi |
| Gene/Transgene symbol | Mrc2 |
Information from provider
| Provider | Clare Isacke |
| Provider affiliation | Institute of Cancer Research |
| Genetic information | Exons 2-6 of the Endo180 (Mrc2) gene were replaced with a PGK-neo cassette. The deleted region includes the N-terminal cysteine-rich domain, the FNII domain and the first C-type lectin-like domain. A truncated transmembrane protein defective in collagen binding is produced but is less stable that the wild-type receptor and is barely detected in the adult animal. |
| Phenotypic information | Homozygous Endo180-DeltaEx2-6/Endo180-DeltaEx2-6 mice are phenotypically normal (at the gross level), healthy and fertile. |
| Breeding history | C57BL/6.129/Sv Endo180-DeltaEx2-6/Endo180-DeltaEx2-6 mice were backcrossed onto C57BL/6 for 7 generations. The strain is currently maintained on C57BL/6. This strain is maintained by mating two homozygous carriers. Expected coat color from breeding: Black. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | homozygous C57BL/6 males |
| Breeding at archiving centre | No breeding was carried out at the archiving centre. |
Disease and phenotype information
Literature references
- A targeted deletion in the endocytic receptor gene Endo180 results in a defect in collagen uptake.;East Lucy, McCarthy Afshan, Wienke Dirk, Sturge Justin, Ashworth Alan, Isacke Clare M, ;2003;EMBO reports;4;710-6; 12835757