B6;129-Klf7^tm1Rmz/Cnrm

Status	Available to order
EMMA ID	EM:04785
International strain name	B6;129-Klf7^tm1Rmz/Cnrm
Alternative name	Klf7 +/-
Strain type	Targeted Mutant Strains : Knock-out
Allele/Transgene symbol	Klf7^tm1Rmz,
Gene/Transgene symbol	Klf7

Information from provider

Provider	Francesco Ramirez
Provider affiliation	Department of Pharmacology and Systems Therapeutics, Mount Sinai School of Medicine
Additional owner	Prof. Bruce Krueger, University of Maryland School of Medicine, Baltimore MD, U.S.A.
Genetic information	The targeting vector was designed to replace most of exon 1 with the phosphoglycerate kinase (PGK)-neo cassette flanked by loxP sites.
Phenotypic information	Klf7 +/- mice display no anatomical abnormalities and are fertile and viable. Klf7 knock-out mice die within 3 days after birth, displaying severely hypoplastic olfactory bulbs, and altered neuronal differentiation in the central nervous system.
Breeding history	The strain was inbred for 4 generations. It is currently bred using Klf7 +/- males and wild-type females.
References	Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous system.;Laub Friedrich, Lei Lei, Sumiyoshi Hideaki, Kajimura Daisuke, Dragomir Cecilia, Smaldone Silvia, Puche Adam C, Petros Timothy J, Mason Carol, Parada Luis F, Ramirez Francesco, ;2005;Molecular and cellular biology;25;5699-711; 15964824
Homozygous fertile	no
Homozygous viable	no
Homozygous matings required	no
Immunocompromised	no

Information from EMMA

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (allele matching)

abnormal nervous system tract morphology / MGI
abnormal corpus callosum morphology / MGI
abnormal telencephalon morphology / MGI
abnormal cerebral cortex morphology / MGI
abnormal dentate gyrus morphology / MGI
abnormal sensory neuron innervation pattern / MGI
unresponsive to tactile stimuli / MGI
cyanosis / MGI
hypopnea / MGI
abnormal brain morphology / MGI
small olfactory bulb / MGI
abnormal axon guidance / MGI
abnormal hippocampal fimbria morphology / MGI
abnormal axon extension / MGI
abnormal olfactory nerve morphology / MGI
absent anterior commissure / MGI
absent gastric milk in neonates / MGI
abnormal hippocampus pyramidal cell morphology / MGI
postnatal lethality, complete penetrance / MGI
abnormal olfactory neuron innervation pattern / MGI

Literature references

Transcription factor KLF7 is important for neuronal morphogenesis in selected regions of the nervous system.;Laub Friedrich, Lei Lei, Sumiyoshi Hideaki, Kajimura Daisuke, Dragomir Cecilia, Smaldone Silvia, Puche Adam C, Petros Timothy J, Mason Carol, Parada Luis F, Ramirez Francesco, ;2005;Molecular and cellular biology;25;5699-711; 15964824

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Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740^*
Rederivation of mice from frozen stock, delivery time available upon request . €3880^*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

^* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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B6;129-Klf7tm1Rmz/Cnrm