MGI phenotypes (allele matching)
B6.129P2-Ryr3tm1Vso/Cnrm
| Status | Available to order |
| EMMA ID | EM:04883 |
| International strain name | B6.129P2-Ryr3tm1Vso/Cnrm |
| Alternative name | Ryr3 KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ryr3tm1Vso, |
| Gene/Transgene symbol | Ryr3 |
Information from provider
| Provider | Vincenzo Sorrentino |
| Provider affiliation | Neuroscience, University of Siena |
| Genetic information | Targeting construct is derived from 129 DNA. Deletion abrogates the last exons encoding the C-terminus of the ryr3 protein, resulting in a nonfunctional and highly unstable protein. |
| Phenotypic information | Mice are viable as homozygous, express no Ryr3 channels and have altered calcium release properties in several tissues. |
| Breeding history | These mice have been bred more than 5 times with C57BL/6. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.;Bertocchini F, Ovitt C E, Conti A, Barone V, Schöler H R, Bottinelli R, Reggiani C, Sorrentino V, ;1997;The EMBO journal;16;6956-63; 9384575