MGI phenotypes (allele matching)
B6.129P2-Ryr3tm1Vso/Cnrm
| Status | Available to order |
| EMMA ID | EM:04883 |
| Citation information | RRID:IMSR_EM:04883 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129P2-Ryr3tm1Vso/Cnrm |
| Alternative name | Ryr3 KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Ryr3tm1Vso |
| Gene/Transgene symbol | Ryr3 |
Information from provider
| Provider | Vincenzo Sorrentino |
| Provider affiliation | Neuroscience, University of Siena |
| Genetic information | Targeting construct is derived from 129 DNA. Deletion abrogates the last exons encoding the C-terminus of the ryr3 protein, resulting in a nonfunctional and highly unstable protein. |
| Phenotypic information | Mice are viable as homozygous, express no Ryr3 channels and have altered calcium release properties in several tissues. |
| Breeding history | These mice have been bred more than 5 times with C57BL/6. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (gene matching)
Literature references
- Requirement for the ryanodine receptor type 3 for efficient contraction in neonatal skeletal muscles.;Bertocchini F, Ovitt C E, Conti A, Barone V, Schöler H R, Bottinelli R, Reggiani C, Sorrentino V, ;1997;The EMBO journal;16;6956-63; 9384575