129-Htr1btm1Rhn/Cnrm

Status

Available to order

EMMA IDEM:05003
International strain name129-Htr1btm1Rhn/Cnrm
Alternative nameHtr1b-KO
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolHtr1btm1Rhn,
Gene/Transgene symbolHtr1b

Information from provider

ProviderRene Hen
Provider affiliationColumbia University
Additional ownerDr Cornelius Gross, EMBL Mouse Biology Unit, Monterotondo/Rome, Italy
Genetic informationThe Htr1b gene was disrupted by insertion of a neomycin resistance cassette into the coding region via homologous recombination.
Phenotypic informationBehavior/neurological: homozygotes display increased aggression, decreased anxiety-related response, abnormal spatial learning, decreased startle reflex.
Breeding historyThe line is maintained by sibling matings.
References
  • Enhanced aggressive behavior in mice lacking 5-HT1B receptor.;Saudou F, Amara D A, Dierich A, LeMeur M, Ramboz S, Segu L, Buhot M C, Hen R, ;1994;Science (New York, N.Y.);265;1875-8; 8091214
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (allele matching)
  • increased osteoblast cell number / MGI
  • increased bone mass / MGI
  • increased bone ossification / MGI
  • small testis / MGI
  • increased body weight / MGI
  • increased aggression towards males / MGI
  • decreased anxiety-related response / MGI
  • abnormal spatial learning / MGI
  • decreased startle reflex / MGI
  • abnormal locomotor activation / MGI
  • increased fluid intake / MGI
  • increased osteoblast proliferation / MGI
  • abnormal operant conditioning behavior / MGI

Literature references

  • Enhanced aggressive behavior in mice lacking 5-HT1B receptor.;Saudou F, Amara D A, Dierich A, LeMeur M, Ramboz S, Segu L, Buhot M C, Hen R, ;1994;Science (New York, N.Y.);265;1875-8; 8091214

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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