B6Dnk;B6Brd;B6N-Tyrc-Brd Hspb11tm1a(EUCOMM)Wtsi/WtsiCnbc

Status

Available to order

EMMA IDEM:05084
Citation informationRRID:IMSR_EM:05084 

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International strain nameB6Dnk;B6Brd;B6N-Tyrc-Brd Hspb11tm1a(EUCOMM)Wtsi/WtsiCnbc
Alternative nameEPD0039_5_B05
Strain typeTargeted Mutant Strains
Allele/Transgene symbolHspb11tm1a(EUCOMM)Wtsi
Gene/Transgene symbolHspb11
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0039_5_B05. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain

Disease and phenotype information

MGI phenotypes (allele matching)
  • increased circulating free fatty acid level / MGI
  • increased circulating glycerol level / MGI
  • abnormal behavior / MGI
  • cleft palate / MGI
  • overriding aortic valve / MGI
  • double outlet right ventricle / MGI
  • abnormal atrioventricular cushion morphology / MGI
  • polydactyly / MGI
  • cyanosis / MGI
  • abnormal neural tube morphology / MGI
  • micrognathia / MGI
  • omphalocele / MGI
  • left pulmonary isomerism / MGI
  • fetal growth retardation / MGI
  • abnormal sternebra morphology / MGI
  • abnormal heart size / MGI
  • decreased birth body size / MGI
  • preaxial polydactyly / MGI
  • small thoracic cage / MGI
  • ventricular septal defect / MGI
  • atrioventricular septal defect / MGI
  • neonatal lethality, complete penetrance / MGI
  • unbalanced complete common atrioventricular canal / MGI
MGI phenotypes (gene matching)
  • cleft palate / MGI
  • overriding aortic valve / MGI
  • double outlet right ventricle / MGI
  • abnormal atrioventricular cushion morphology / MGI
  • polydactyly / MGI
  • increased circulating free fatty acid level / MGI
  • cyanosis / MGI
  • abnormal neural tube morphology / MGI
  • micrognathia / MGI
  • omphalocele / MGI
  • left pulmonary isomerism / MGI
  • increased circulating glycerol level / MGI
  • fetal growth retardation / MGI
  • abnormal sternebra morphology / MGI
  • abnormal behavior / MGI
  • abnormal heart size / MGI
  • decreased birth body size / MGI
  • preaxial polydactyly / MGI
  • small thoracic cage / MGI
  • ventricular septal defect / MGI
  • atrioventricular septal defect / MGI
  • neonatal lethality, complete penetrance / MGI
  • unbalanced complete common atrioventricular canal / MGI

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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