STOCK Hprttm1.1(CMA1)/Ieg
| Status | Under development - register interest |
| EMMA ID | EM:05206 |
| International strain name | STOCK Hprttm1.1(CMA1)/Ieg |
| Alternative name | hCMA1 Cre-excised |
| Strain type | Targeted Mutant Strains : Knock-in |
| Allele/Transgene symbol | Hprttm1.1(CMA1) |
| Gene/Transgene symbol | Hprt1 |
Information from provider
| Provider | Katrin Hoffmann |
| Provider affiliation | Clinical Candidate Selection Unit, Abbott Pharmaceuticals GmbH |
| Genetic information | This project is conducted to develop a mouse line carrying the human chymase 1 (CMA1) cDNA under the control of an ubiquitous promoter. This model is developed in order to allow the overexpression of the human CMA1 gene. This model has been developed using the "Quick Knock-inTM" approach. The hCMA1 cDNA transgene was introduced into the Hprt locus by knock-in using genOway's ready to use "Quick Knock-inTM" targeting vector. In addition, the expression was conditionally turned on using genOway's floxed transcriptional STOP cassette. The expression of the transgene was induced through removal of this cassette following cre recombinase action by breeding the chimeras with either ubiquitous CMV-cre or tissue-specific cre recombinase-expressing mice. |
| Phenotypic information | None. |
| References | None available |
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | not known |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |