IMPC phenotypes (allele matching)
C57BL/6N-Sirt6tm1a(EUCOMM)Wtsi/H
| Status | Available to order |
| EMMA ID | EM:05219 |
| Citation information | RRID:IMSR_EM:05219 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Sirt6tm1a(EUCOMM)Wtsi/H |
| Alternative name | EPD0256_5_F08 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Sirt6tm1a(EUCOMM)Wtsi |
| Gene/Transgene symbol | Sirt6 |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | MRC, Medical Research Council |
| Provider affiliation | Mary Lyon Centre at MRC Harwell |
| Genetic information | This mouse line originates from EUCOMM ES clone EPD0256_5_F08. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | heterozygous C57BL/6NTac males |
| Breeding at archiving centre | Chimeras were mated to C57BL/6N Tac USA and maintained on this background thereafter. |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Lethal brain and heart developmental defects / Orphanet_580933
MGI phenotypes (gene matching)
- decreased bone mineral density / MGI
- malocclusion / MGI
- kyphosis / MGI
- lordosis / MGI
- hypoglycemia / MGI
- decreased leukocyte cell number / MGI
- decreased bone marrow cell number / MGI
- decreased cell proliferation / MGI
- spleen hypoplasia / MGI
- decreased body length / MGI
- decreased body weight / MGI
- decreased body size / MGI
- abnormal nursing / MGI
- postnatal growth retardation / MGI
- reduced female fertility / MGI
- male infertility / MGI
- abnormal glucose homeostasis / MGI
- premature death / MGI
- abnormal eye morphology / MGI
- abnormal B cell differentiation / MGI
- abnormal lymphopoiesis / MGI
- decreased circulating insulin level / MGI
- colitis / MGI
- increased insulin sensitivity / MGI
- premature aging / MGI
- spontaneous chromosome breakage / MGI
- increased cellular sensitivity to ionizing radiation / MGI
- decreased circulating insulin-like growth factor I level / MGI
- decreased double-positive T cell number / MGI
- narrow eye opening / MGI
- decreased circulating glucose level / MGI
- early cellular replicative senescence / MGI
- increased cellular sensitivity to alkylating agents / MGI
- abnormal spleen physiology / MGI
- decreased subcutaneous adipose tissue amount / MGI
- decreased total body fat amount / MGI
- lethality at weaning, complete penetrance / MGI