B6Dnk;B6Brd;B6N-Tyr^c-Brd Cdh1^{tm1a(EUCOMM)Wtsi}/WtsiCnbc

Status	Available to order
EMMA ID	EM:05235
Citation information	RRID:IMSR_EM:05235 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	B6Dnk;B6Brd;B6N-Tyr^c-Brd Cdh1^{tm1a(EUCOMM)Wtsi}/WtsiCnbc
Alternative name	EPD0036_1_G01
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Cdh1^{tm1a(EUCOMM)Wtsi}
Gene/Transgene symbol	Cdh1
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Provider	Wellcome Trust Sanger Institute
Provider affiliation	Wellcome Trust Sanger Institute
Genetic information	This mouse line originates from EUCOMM ES clone EPD0036_1_G01. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Archiving centre	CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain

Orphanet associated rare diseases, based on orthologous gene matching

IMPC phenotypes (allele matching)

IMPC phenotypes (gene matching)

MGI phenotypes (gene matching)

abnormal embryo development / MGI
abnormal placenta morphology / MGI
placental labyrinth hypoplasia / MGI
pale yolk sac / MGI
embryonic growth arrest / MGI
prenatal lethality / MGI
abnormal embryonic tissue morphology / MGI
abnormal extraembryonic tissue morphology / MGI
increased susceptibility to bacterial infection / MGI
absent blastocoele / MGI
no phenotypic analysis / MGI
failure of blastocyst to hatch from the zona pellucida / MGI
pallor / MGI
abnormal trophectoderm morphology / MGI
abnormal trophoblast layer morphology / MGI
abnormal placental labyrinth vasculature morphology / MGI
abnormal enterocyte physiology / MGI
empty decidua capsularis / MGI
abnormal preimplantation embryo development / MGI
abnormal placenta physiology / MGI
prenatal lethality, complete penetrance / MGI
embryonic lethality, complete penetrance / MGI
embryonic lethality before implantation, complete penetrance / MGI
embryonic lethality between implantation and somite formation, complete penetrance / MGI
embryonic lethality during organogenesis, complete penetrance / MGI
decreased placental labyrinth size / MGI
absent trophectoderm / MGI
failure of morula compaction / MGI
increased trophectoderm apoptosis / MGI

Information from provider