IMPC phenotypes (gene matching)
B6;129-Hint1tm1Ibw/Ieg
| Status | Available to order |
| EMMA ID | EM:05279 |
| Citation information | RRID:IMSR_EM:05279 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129-Hint1tm1Ibw/Ieg |
| Alternative name | HINT1 Knockout mice |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Hint1tm1Ibw |
| Gene/Transgene symbol | Hint1 |
Information from provider
| Provider | Christoph Turck |
| Provider affiliation | Molecular Neurogenetics, Max Planck Institute of Psychiatry |
| Additional owner | Dr. Haiyang Li, Herbert Comprehensive Cancer Center, Columbia University Medical Center, NY, United States |
| Genetic information | This mouse line was originally created by Dr. I. Bernard Weinstein. Those mice were infected with some pathogens. Due to this reason, a new embryo transfer into foster mothers was done. |
| Phenotypic information | Hint1 knock-out mice exhibited more anxiety-related behaviour than wild-type mice in elevated plus-maze and dark light-box test. |
| Breeding history | For 6 generations the heterozygous male and female mice were mated to generate the homozygous mice. |
| References |
|
| Homozygous fertile | not known |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | Helmholtz Zentrum Muenchen - German Research Center for Environmental Health (GmbH), Oberschleißheim, Germany |
| Animals used for archiving | heterozygous C57BL/6N males, wild-type C57BL/6N females |
| Stage of embryos | 2-cell |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Autosomal recessive axonal neuropathy with neuromyotonia / Orphanet_324442
Literature references
- The HINT1 tumor suppressor regulates both gamma-H2AX and ATM in response to DNA damage.;Li Haiyang, Balajee Adayabalam S, Su Tao, Cen Bo, Hei Tom K, Weinstein I Bernard, ;2008;The Journal of cell biology;183;253-65; 18852295
- Hint1 is a haplo-insufficient tumor suppressor in mice.;Li H, Zhang Y, Su T, Santella R M, Weinstein I B, ;2006;Oncogene;25;713-21; 16186798
- Deletion of histidine triad nucleotide-binding protein 1/PKC-interacting protein in mice enhances cell growth and carcinogenesis.;Su Tao, Suzui Masumi, Wang Lei, Lin Chyuan-Sheng, Xing Wang-Qiu, Weinstein I Bernard, ;2003;Proceedings of the National Academy of Sciences of the United States of America;100;7824-9; 12810953
- Increased anxiety-related behaviour in Hint1 knockout mice.;Varadarajulu Jeeva, Lebar Maria, Krishnamoorthy Gurumoorthy, Habelt Sonja, Lu Jia, Bernard Weinstein I, Li Haiyang, Holsboer Florian, Turck Christoph W, Touma Chadi, ;2011;Behavioural brain research;220;305-11; 21316396