C57BL/6NTac-Becn1^{tm1a(KOMP)Wtsi}/Cnrm

Status	Available to order
EMMA ID	EM:05360
Citation information	RRID:IMSR_EM:05360 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.
International strain name	C57BL/6NTac-Becn1^{tm1a(KOMP)Wtsi}/Cnrm
Alternative name	EPD0168_1_H11
Strain type	Targeted Mutant Strains
Allele/Transgene symbol	Becn1^{tm1a(KOMP)Wtsi}
Gene/Transgene symbol	Becn1
Disclaimer	Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA: We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Provider	CNR, Consiglio Nazionale delle Ricerche
Provider affiliation	EMMA-Monterotondo Campus International Development, CNR, Consiglio Nazionale delle Ricerche
Genetic information	This mouse line originates from KOMP ES clone EPD0168_1_H11. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic information	Potential phenotyping data in the IMPC portal
References	None available

Archiving centre	CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

IMPC phenotypes (gene matching)

MGI phenotypes (gene matching)

abnormal immune system morphology / MGI
abnormal ovary morphology / MGI
decreased embryo size / MGI
absent amniotic folds / MGI
embryonic growth arrest / MGI
increased malignant tumor incidence / MGI
increased tumor incidence / MGI
increased B cell derived lymphoma incidence / MGI
increased lung adenocarcinoma incidence / MGI
increased lung adenoma incidence / MGI
premature death / MGI
increased myocardial infarction size / MGI
decreased myocardial infarction size / MGI
increased hepatocellular carcinoma incidence / MGI
abnormal amnion morphology / MGI
abnormal autophagy / MGI
increased spleen germinal center number / MGI
increased spleen germinal center size / MGI
increased lung carcinoma incidence / MGI
increased follicular lymphoma incidence / MGI
increased histiocytic sarcoma incidence / MGI
abnormal mammary gland duct morphology / MGI
increased plasmacytoma incidence / MGI
increased mammary gland tumor incidence / MGI
prenatal lethality, complete penetrance / MGI
embryonic lethality between implantation and somite formation, complete penetrance / MGI
increased lymphoma incidence / MGI
increased embryonic tissue cell apoptosis / MGI

Information from provider