MGI phenotypes (allele matching)
- decreased neutrophil cell number / MGI
FVB.129P2-Csf3rtm2Eur/Cnrm
| Status | Available to order |
| EMMA ID | EM:00054 |
| International strain name | FVB.129P2-Csf3rtm2Eur/Cnrm |
| Alternative name | Csfgr-KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Csf3rtm2Eur, |
| Gene/Transgene symbol | Csf3r |
Information from provider
| Provider | Mirjam Hermans |
| Provider affiliation | Erasmus Univ.-Inst. Hematology |
| Genetic information | Inactivation of the Csf3r (Csfgr, G-CSFR) gene. Exons 7 to 17 are replaced by a PGK-neo gene (the total number of exons in the Csf3r gene is 17). |
| Phenotypic information | Reduced numbers of bone marrow and blood neutrophils. |
| References | None available |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Chronic neutrophilic leukemia / Orphanet_86829
- Atypical chronic myeloid leukemia / Orphanet_98824
- Autosomal recessive severe congenital neutropenia due to CSF3R deficiency / Orphanet_420702
- Hereditary neutrophilia / Orphanet_279943