C57BL/6N-Sirt1tm1a(EUCOMM)Wtsi/H

Status

Available to order

EMMA IDEM:05484
Citation informationRRID:IMSR_EM:05484 

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International strain nameC57BL/6N-Sirt1tm1a(EUCOMM)Wtsi/H
Alternative nameEPD0428_2_B04
Strain typeTargeted Mutant Strains
Allele/Transgene symbolSirt1tm1a(EUCOMM)Wtsi
Gene/Transgene symbolSirt1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider MRC, Medical Research Council
Provider affiliationMary Lyon Centre at MRC Harwell
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0428_2_B04. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreMary Lyon Centre at MRC Harwell, Oxford, United Kingdom

Disease and phenotype information

IMPC phenotypes (gene matching)
  • increased basophil cell number / IMPC
  • abnormal sinus arrhythmia / IMPC
  • abnormal pelvic girdle bone morphology / IMPC
  • preweaning lethality, incomplete penetrance / IMPC
  • abnormal snout morphology / IMPC
  • abnormal tooth morphology / IMPC
  • abnormal maxilla morphology / IMPC
  • abnormal iris morphology / IMPC
  • narrow eye opening / IMPC
  • abnormal scapula morphology / IMPC
MGI phenotypes (gene matching)
  • abnormal heart development / MGI
  • enlarged heart / MGI
  • heart right ventricle hypertrophy / MGI
  • abnormal cell death / MGI
  • abnormal craniofacial morphology / MGI
  • abnormal head morphology / MGI
  • short snout / MGI
  • abnormal salivary gland morphology / MGI
  • abnormal mammary gland morphology / MGI
  • abnormal branching of the mammary ductal tree / MGI
  • enlarged spleen / MGI
  • exencephaly / MGI
  • abnormal retinal photoreceptor morphology / MGI
  • small ovary / MGI
  • absent corpus luteum / MGI
  • small seminiferous tubules / MGI
  • arrest of spermatogenesis / MGI
  • abnormal spermatogenesis / MGI
  • decreased body weight / MGI
  • decreased body size / MGI
  • abnormal eye development / MGI
  • microphthalmia / MGI
  • abnormal eyelid morphology / MGI
  • abnormal lacrimal gland morphology / MGI
  • abnormal nursing / MGI
  • hypoactivity / MGI
  • polydipsia / MGI
  • polyphagia / MGI
  • decreased embryo size / MGI
  • postnatal growth retardation / MGI
  • decreased white adipose tissue amount / MGI
  • lung inflammation / MGI
  • interstitial pneumonia / MGI
  • reduced male fertility / MGI
  • reduced female fertility / MGI
  • male infertility / MGI
  • female infertility / MGI
  • abnormal estrous cycle / MGI
  • increased cellular sensitivity to gamma-irradiation / MGI
  • abnormal glucose homeostasis / MGI
  • perinatal lethality / MGI
  • postnatal lethality / MGI
  • premature death / MGI
  • abnormal eye morphology / MGI
  • no abnormal phenotype detected / MGI
  • decreased brain weight / MGI
  • abnormal seminiferous tubule morphology / MGI
  • increased immunoglobulin level / MGI
  • asthenozoospermia / MGI
  • globozoospermia / MGI
  • oligozoospermia / MGI
  • decreased circulating insulin level / MGI
  • glomerulonephritis / MGI
  • abnormal atrioventricular valve morphology / MGI
  • decreased circulating luteinizing hormone level / MGI
  • abnormal testes secretion / MGI
  • decreased circulating follicle stimulating hormone level / MGI
  • decreased urine osmolality / MGI
  • no phenotypic analysis / MGI
  • increased insulin secretion / MGI
  • enlarged pancreas / MGI
  • abnormal chromosome morphology / MGI
  • increased autoantibody level / MGI
  • abnormal retinal layer morphology / MGI
  • pulmonary edema / MGI
  • aneuploidy / MGI
  • abnormal cell cycle checkpoint function / MGI
  • abnormal Sertoli cell development / MGI
  • increased cellular sensitivity to ionizing radiation / MGI
  • increased mitotic index / MGI
  • increased anti-nuclear antigen antibody level / MGI
  • decreased testis weight / MGI
  • abnormal uterus size / MGI
  • eyelids fail to open / MGI
  • lethargy / MGI
  • increased brain size / MGI
  • increased oxygen consumption / MGI
  • abnormal glucose tolerance / MGI
  • abnormal renal glomerulus morphology / MGI
  • abnormal inguinal fat pad morphology / MGI
  • immune system phenotype / MGI
  • reproductive system phenotype / MGI
  • abnormal energy expenditure / MGI
  • decreased circulating thyroxine level / MGI
  • Leydig cell hypoplasia / MGI
  • teratozoospermia / MGI
  • ocular hypotelorism / MGI
  • abnormal mammary gland growth during pregnancy / MGI
  • abnormal digit development / MGI
  • abnormal spermatocyte morphology / MGI
  • abnormal spermatid morphology / MGI
  • abnormal DNA replication / MGI
  • abnormal DNA repair / MGI
  • decreased CD8-positive, alpha-beta T cell number / MGI
  • arrest of male meiosis / MGI
  • abnormal male germ cell apoptosis / MGI
  • increased cellular sensitivity to ultraviolet irradiation / MGI
  • slow postnatal weight gain / MGI
  • disorganized retinal inner nuclear layer / MGI
  • disorganized retinal outer nuclear layer / MGI
  • decreased survivor rate / MGI
  • anovulation / MGI
  • abnormal sperm flagellum morphology / MGI
  • absent estrous cycle / MGI
  • exocrine pancreas atrophy / MGI
  • abnormal palatal rugae morphology / MGI
  • decreased respiratory quotient / MGI
  • ventricular septal defect / MGI
  • atrial septal defect / MGI
  • mortality/aging / MGI
  • hyperpnea / MGI
  • abnormal cellular respiration / MGI
  • postnatal lethality, complete penetrance / MGI
  • postnatal lethality, incomplete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • perinatal lethality, incomplete penetrance / MGI
  • embryonic lethality during organogenesis, incomplete penetrance / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • increased urine antidiuretic hormone level / MGI
  • abnormal seminiferous tubule epithelium morphology / MGI
  • increased food intake / MGI
  • hypoactivity in response to feed restriction / MGI
  • absent hindlimb buds / MGI
  • abnormal adult Leydig cell differentiation / MGI
  • hypolactation / MGI
  • renal glomerular immunoglobulin deposits / MGI
  • multinucleated giant male germ cells / MGI

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