IMPC phenotypes (gene matching)
B6;129P2-Tiam1tm1Jgc/Cnbc
| Status | Available to order |
| EMMA ID | EM:05563 |
| Citation information | RRID:IMSR_EM:05563 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6;129P2-Tiam1tm1Jgc/Cnbc |
| Alternative name | C57BL/6-Tiam1 KO |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Tiam1tm1Jgc |
| Gene/Transgene symbol | Tiam1 |
Information from provider
| Provider | John Collard |
| Provider affiliation | Research - Animal Facility, The Netherlands Cancer Institute |
| Genetic information | Mice that are deficient for the Rac activator Tiam1. |
| Phenotypic information | Mice do not have an obvious phenotype and are fertile. However tumorigenicity is highly affected. In general tumor formation and growth is reduced but metastasis is enhanced. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | not known |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | heterozygous C57BL/6J males |
Disease and phenotype information
MGI phenotypes (gene matching)
- decreased cell proliferation / MGI
- abnormal forebrain morphology / MGI
- abnormal diencephalon morphology / MGI
- exencephaly / MGI
- abnormal apoptosis / MGI
- anencephaly / MGI
- increased malignant tumor incidence / MGI
- increased squamous cell carcinoma incidence / MGI
- decreased incidence of tumors by chemical induction / MGI
Literature references
- Mice deficient in the Rac activator Tiam1 are resistant to Ras-induced skin tumours.;Malliri Angeliki, van der Kammen Rob A, Clark Kristopher, van der Valk Maarten, Michiels Frits, Collard John G, ;2002;Nature;417;867-71; 12075356
- The rac activator Tiam1 is a Wnt-responsive gene that modifies intestinal tumor development.;Malliri Angeliki, Rygiel Tomasz P, van der Kammen Rob A, Song Ji-Ying, Engers Rainer, Hurlstone Adam F L, Clevers Hans, Collard John G, ;2006;The Journal of biological chemistry;281;543-8; 16249175
- Prognostic relevance of Tiam1 protein expression in prostate carcinomas.;Engers R, Mueller M, Walter A, Collard J G, Willers R, Gabbert H E, ;2006;British journal of cancer;95;1081-6; 17003780
- Tiam1-deficiency impairs mammary tumor formation in MMTV-c-neu but not in MMTV-c-myc mice.;Strumane K, Rygiel T, van der Valk M, Collard J G, ;2009;Journal of cancer research and clinical oncology;135;69-80; 18592271
- Increased Rac activity is required for the progression of T-lymphomas induced by Pten-deficiency.;Strumane Kristin, Song Ji-Ying, Baas Inge, Collard John G, ;2008;Leukemia research;32;113-20; 17521720