B6.Cg-Piwil1tm1.1Embrp/Cnrm
Status | Available to order |
EMMA ID | EM:05595 |
International strain name | B6.Cg-Piwil1tm1.1Embrp/Cnrm |
Alternative name | Miwi Slicer mutant |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Piwil1tm1.1Embrp, |
Gene/Transgene symbol | Piwil1 |
Information from provider
Provider | Ramesh PILLAI |
Provider affiliation | Mouse Biology Unit, European Molecular Biology Laboratory |
Genetic information | Piwil1 (Miwi) knock-in allele. Carries a single amino acid mutation ADH (D633A). Inactivates the slicer (small RNA-guided RNase) activity. |
Phenotypic information | Only males show infertility. Block in spermatogenesis at elongating spermatids. Dominant negative. |
References |
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Homozygous fertile | no |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Miwi catalysis is required for piRNA amplification-independent LINE1 transposon silencing.;Reuter Michael, Berninger Philipp, Chuma Shinichiro, Shah Hardik, Hosokawa Mihoko, Funaya Charlotta, Antony Claude, Sachidanandam Ravi, Pillai Ramesh S, ;2011;Nature;480;264-7; 22121019
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