- decreased brain size / MGI
- abnormal cerebellar foliation / MGI
- abnormal midbrain morphology / MGI
- abnormal telencephalon development / MGI
- abnormal iris morphology / MGI
- absent lacrimal glands / MGI
- abnormal eye morphology / MGI
- decreased brain weight / MGI
- decreased superior colliculus size / MGI
- absent lateral semicircular canal / MGI
- nervous system phenotype / MGI
- behavior/neurological phenotype / MGI
- absent Harderian gland / MGI
- decreased inferior colliculus size / MGI
- postnatal lethality, incomplete penetrance / MGI
STOCK Otx1tm2(otd)Asim/Cnrm
Status | Available to order |
EMMA ID | EM:05621 |
International strain name | STOCK Otx1tm2(otd)Asim/Cnrm |
Alternative name | Otx1-Otd |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Otx1tm2(otd)Asim, |
Gene/Transgene symbol | Otx1 |
Information from provider
Provider | Antonio Simeone |
Provider affiliation | Ceinge Biotecnologie Avanzate |
Genetic information | Otx1 exon 1 and 2 are replaced with Drosophila Otd gene by homologous recombination. |
Phenotypic information | Rescue of the epileptic behaviour and size of brain, defects of the inner ear. |
Breeding history | Targeted mutation was introduced in HM-1 ES cells. Mice were always maintained in a mixed C57BL/6 and DBA/2 genetic background. |
References |
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Homozygous fertile | not known |
Homozygous viable | yes |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Otx genes in evolution: are they involved in instructing the vertebrate brain morphology?;Acampora D, Boyl P P, Martinez-Barbera J P, Annino A, Signore M, Simeone A, ;2001;Journal of anatomy;199;53-62; 11523829
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