B6.Cg-Tg(Pklr-BCL2)BAk/Orl
| Status | Available to order |
| EMMA ID | EM:05819 |
| Citation information | RRID:IMSR_EM:05819 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.Cg-Tg(Pklr-BCL2)BAk/Orl |
| Alternative name | LPK-Bcl-2 |
| Strain type | Transgenic Strains |
| Allele/Transgene symbol | Tg(Pklr-BCL2)BAk |
| Gene/Transgene symbol | Tg(Pklr-BCL2)BAk |
Information from provider
| Provider | Helene Gilgenkrantz |
| Provider affiliation | Endocrinology Metabolism Cancer, Institut Cochin INSERM U567 |
| Genetic information | Additive transgenic mouse strain expressing the human Bcl-2 cDNA under the regulatory sequences of the rat L-pyruvate kinase promoter. The expression of the transgene is mainly in the liver, kidney and intestine and weakly in pancreas. |
| Phenotypic information | No phenotype at quiescent stage but a protection against liver apoptosis, ischemia reperfusion lesions and mitochondrial dysfunction. |
| Breeding history | More than 30 backcrosses to C57BL/6 background. |
| References |
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| Homozygous fertile | not known |
| Homozygous viable | not known |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
| Animals used for archiving | heterozygous C57BL/6J males, wild-type C57BL/6J females |
Literature references
- Bcl-2 protects from lethal hepatic apoptosis induced by an anti-Fas antibody in mice.;Lacronique V, Mignon A, Fabre M, Viollet B, Rouquet N, Molina T, Porteu A, Henrion A, Bouscary D, Varlet P, Joulin V, Kahn A, ;1996;Nature medicine;2;80-6; 8564847
- Selective repopulation of normal mouse liver by Fas/CD95-resistant hepatocytes.;Mignon A, Guidotti J E, Mitchell C, Fabre M, Wernet A, De La Coste A, Soubrane O, Gilgenkrantz H, Kahn A, ;1998;Nature medicine;4;1185-8; 9771754
- Bone marrow transplantation in mice leads to a minor population of hepatocytes that can be selectively amplified in vivo.;Mallet Vincent O, Mitchell Claudia, Mezey Eva, Fabre Monique, Guidotti Jacques-Emmanuel, Renia Laurent, Coulombel Laure, Kahn Axel, Gilgenkrantz Hélène, ;2002;Hepatology (Baltimore, Md.);35;799-804; 11915025
- The combination of ischemic preconditioning and liver Bcl-2 overexpression is a suitable strategy to prevent liver and lung damage after hepatic ischemia-reperfusion.;Peralta Carmen, Perales José Carlos, Bartrons Ramón, Mitchell Claudia, Gilgenkrantz Hélène, Xaus Carme, Prats Neus, Fernández Leticia, Gelpí Emilio, Panés Julia, Roselló-Catafau Juan, ;2002;The American journal of pathology;160;2111-22; 12057915
- Protection against hepatocyte mitochondrial dysfunction delays fibrosis progression in mice.;Mitchell Claudia, Robin Marie-Anne, Mayeuf Alicia, Mahrouf-Yorgov Meriem, Mansouri Abdellah, Hamard Marie, Couton Dominique, Fromenty Bernard, Gilgenkrantz Hélène, ;2009;The American journal of pathology;175;1929-37; 19808650
- Overexpression of Bcl-2 in hepatocytes protects against injury but does not attenuate fibrosis in a mouse model of chronic cholestatic liver disease.;Mitchell Claudia, Mahrouf-Yorgov Meriem, Mayeuf Alicia, Robin Marie-Anne, Mansouri Abdellah, Fromenty Bernard, Gilgenkrantz Hélène, ;2011;Laboratory investigation; a journal of technical methods and pathology;91;273-82; 20856227