B6.129-Sgcetm1Vinni Sgcatm1Kcam/Cnrm

Status

Available to order

EMMA IDEM:05841
International strain nameB6.129-Sgcetm1Vinni Sgcatm1Kcam/Cnrm
Alternative nameSgcaSgcetm1Vinni Sgca/Sgce DKO
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolSgcetm1Vinni,
Gene/Transgene symbolSgce

Information from provider

ProviderVincenzo Nigro
Provider affiliationTIGEM
Genetic informationTo understand the role of epsilon-SG in skeletal and cardiac muscle, we engineered an Sgce-null mouse. In addition, to investigate the impact of the concomitant loss of alpha- and epsilon-SG, we generated an Sgca/Sgce null mouse that lacks SGs.
Phenotypic informationThe Sgca/Sgce null mouse developed a progressive muscular dystrophy and a more anticipated and severe cardiomyopathy.
References
  • Combined deficiency of alpha and epsilon sarcoglycan disrupts the cardiac dystrophin complex.;Lancioni Alessio, Rotundo Ida Luisa, Kobayashi Yvonne Monique, D'Orsi Luca, Aurino Stefania, Nigro Gerardo, Piluso Giulio, Acampora Dario, Cacciottolo Mafalda, Campbell Kevin P, Nigro Vincenzo, ;2011;Human molecular genetics;20;4644-54; 21890494
Homozygous fertileyes
Homozygous viableyes
Homozygous matings requiredyes
Immunocompromisedno

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • dystrophic muscle / MGI
  • heart inflammation / MGI
  • abnormal skeletal muscle fiber morphology / MGI
  • cardiac fibrosis / MGI
  • calcified muscle / MGI
  • abnormal muscle fiber morphology / MGI
  • abnormal sarcolemma morphology / MGI
  • cardiomyopathy / MGI
  • muscle phenotype / MGI
  • abnormal muscle contractility / MGI
  • centrally nucleated skeletal muscle fibers / MGI
  • increased extensor digitorum longus weight / MGI
  • increased soleus weight / MGI
  • increased circulating creatine kinase level / MGI
  • abnormal circulating pyruvate kinase level / MGI
  • cardiac muscle necrosis / MGI
  • cardiovascular system phenotype / MGI

Literature references

  • Combined deficiency of alpha and epsilon sarcoglycan disrupts the cardiac dystrophin complex.;Lancioni Alessio, Rotundo Ida Luisa, Kobayashi Yvonne Monique, D'Orsi Luca, Aurino Stefania, Nigro Gerardo, Piluso Giulio, Acampora Dario, Cacciottolo Mafalda, Campbell Kevin P, Nigro Vincenzo, ;2011;Human molecular genetics;20;4644-54; 21890494

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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