B6.Cg-Pax3tm2.2(Pax3/7.1)Ins/Orl

Status

Available to order

EMMA IDEM:05846
Citation informationRRID:IMSR_EM:05846 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameB6.Cg-Pax3tm2.2(Pax3/7.1)Ins/Orl
Alternative nameB6.Pax3AmphiPax37/+
Strain typeTargeted Mutant Strains : Knock-in
Allele/Transgene symbolPax3tm2.2(Pax3/7.1)Ins
Gene/Transgene symbolPax3

Information from provider

ProviderFrederic RELAIX
Provider affiliationGroupe Myologie, UMR-S 787 - INSERM - UPMC-Paris VI - Institut de Myologie
Genetic informationThis line has been derived from the B6.Pax3Amphi37-ILZ/+ (EMMA ID EM:05827) in which the Amphioxus Pax3/7 cDNA followed by the IRESLacZ gene has been introduced in the Pax3 locus. To generate this line, B6.Pax3Amphi37-ILZ/+ have been crossed with a FLP-expressing line (removing the LacZ gene). Floxed and FRT flanked cassettes have been removed: one FRT and one loxP site remain in the genome.
Phenotypic informationThe heterozygous mice are viable, fertile and present a white belly spot. Homozygous lethality.
Breeding historyHeterozygotes are viable and fertile. Homozygous lethality. Heterozygous males are crossed to C57BL/6 females. The line has been backcrossed to C57BL/6 background for at least 5 generations.
ReferencesNone available
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous C57BL/6J males

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (gene matching)
  • thin ventricular wall / MGI
  • abnormal interventricular septum morphology / MGI
  • double outlet right ventricle / MGI
  • decreased cell proliferation / MGI
  • diluted coat color / MGI
  • belly spot / MGI
  • abnormal hindlimb morphology / MGI
  • kinked tail / MGI
  • abnormal thyroid gland morphology / MGI
  • abnormal thymus morphology / MGI
  • abnormal myogenesis / MGI
  • abnormal muscle development / MGI
  • abnormal myotome development / MGI
  • abnormal skeletal muscle morphology / MGI
  • thin diaphragm muscle / MGI
  • abnormal brain ventricle morphology / MGI
  • abnormal lateral ventricle morphology / MGI
  • abnormal hindbrain morphology / MGI
  • exencephaly / MGI
  • incomplete rostral neuropore closure / MGI
  • open neural tube / MGI
  • small embryonic telencephalon / MGI
  • abnormal spinal cord morphology / MGI
  • abnormal dorsal root ganglion morphology / MGI
  • disorganized dorsal root ganglion / MGI
  • absent skin pigmentation / MGI
  • decreased body size / MGI
  • cyanosis / MGI
  • abnormal somite development / MGI
  • failure to gastrulate / MGI
  • decreased embryo size / MGI
  • respiratory distress / MGI
  • neoplasm / MGI
  • abnormal coat/hair pigmentation / MGI
  • abnormal limb morphology / MGI
  • abnormal tail morphology / MGI
  • abnormal neural tube morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal pulmonary alveolus morphology / MGI
  • abnormal thymus lobule morphology / MGI
  • abnormal semicircular canal morphology / MGI
  • delayed neural tube closure / MGI
  • persistent truncus arteriosis / MGI
  • abnormal pharyngeal arch artery morphology / MGI
  • dilated heart left ventricle / MGI
  • dilated heart right ventricle / MGI
  • white spotting / MGI
  • head spot / MGI
  • variable body spotting / MGI
  • abnormal neural crest cell migration / MGI
  • small thyroid gland / MGI
  • ectopic thymus / MGI
  • no phenotypic analysis / MGI
  • curly tail / MGI
  • spina bifida / MGI
  • abnormal muscle precursor cell migration / MGI
  • decreased cochlear coiling / MGI
  • nervous system phenotype / MGI
  • abnormal midbrain development / MGI
  • abnormal tongue muscle morphology / MGI
  • retroesophageal right subclavian artery / MGI
  • abnormal dermomyotome development / MGI
  • abnormal myocardial fiber physiology / MGI
  • abnormal bony labyrinth / MGI
  • increased mitotic index / MGI
  • abnormal neural fold elevation formation / MGI
  • absent skeletal muscle / MGI
  • absent ultimobranchial body / MGI
  • absent coat pigmentation / MGI
  • absent thyroid gland / MGI
  • hearing/vestibular/ear phenotype / MGI
  • embryo phenotype / MGI
  • cardiovascular system phenotype / MGI
  • vision/eye phenotype / MGI
  • hypopigmentation / MGI
  • decreased ventricle muscle contractility / MGI
  • abnormal endolymphatic duct morphology / MGI
  • abnormal otic vesicle development / MGI
  • abnormal vena cava morphology / MGI
  • abnormal vestibular saccule morphology / MGI
  • abnormal utricle morphology / MGI
  • abnormal cardiac outflow tract development / MGI
  • congestive heart failure / MGI
  • absent hypaxial muscle / MGI
  • abnormal sixth pharyngeal arch artery morphology / MGI
  • short endolymphatic duct / MGI
  • abnormal ventral coat pigmentation / MGI
  • absent dorsal root ganglion / MGI
  • embryonic lethality / MGI
  • caudal rachischisis / MGI
  • abnormal tail hair pigmentation / MGI
  • abnormal hind foot hair pigmentation / MGI
  • variable depigmentation / MGI
  • transverse fur striping / MGI
  • ventricular septal defect / MGI
  • muscular ventricular septal defect / MGI
  • persistent right dorsal aorta / MGI
  • common truncal valve / MGI
  • patent tricuspid valve / MGI
  • dilated pulmonary trunk / MGI
  • thick interventricular septum / MGI
  • integument phenotype / MGI
  • postnatal lethality, complete penetrance / MGI
  • neonatal lethality, incomplete penetrance / MGI
  • perinatal lethality, complete penetrance / MGI
  • prenatal lethality, complete penetrance / MGI
  • embryonic lethality between implantation and somite formation, complete penetrance / MGI
  • embryonic lethality during organogenesis, complete penetrance / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • prenatal lethality, incomplete penetrance / MGI
  • embryonic lethality, incomplete penetrance / MGI
  • embryonic lethality during organogenesis, incomplete penetrance / MGI
  • lethality throughout fetal growth and development, incomplete penetrance / MGI
  • decreased tail pigmentation / MGI
  • abnormal diaphragm development / MGI
  • spina bifida cystica / MGI
  • increased embryonic neuroepithelium apoptosis / MGI
  • abnormal common carotid artery morphology / MGI
  • abnormal mammary line morphology / MGI
  • abnormal mammary placode morphology / MGI
  • abnormal embryo morphology / MGI
  • abnormal hypoglossal cord morphology / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

Other EMMA strains

Not found what you were looking for? Search here for other strains available from EMMA.


Search
INFRAFRONTIER® and European Mouse Mutant Archive - EMMA® are registered trademarks at the European Union Intellectual Property Office (EUIPO).