B6.Cg-Pax3tm2.2(Pax3/7.1)Ins/Orl
Status | Available to order |
EMMA ID | EM:05846 |
International strain name | B6.Cg-Pax3tm2.2(Pax3/7.1)Ins/Orl |
Alternative name | B6.Pax3AmphiPax37/+ |
Strain type | Targeted Mutant Strains : Knock-in |
Allele/Transgene symbol | Pax3tm2.2(Pax3/7.1)Ins, |
Gene/Transgene symbol | Pax3 |
Information from provider
Provider | Frederic RELAIX |
Provider affiliation | Groupe Myologie, UMR-S 787 - INSERM - UPMC-Paris VI - Institut de Myologie |
Genetic information | This line has been derived from the B6.Pax3Amphi37-ILZ/+ (EMMA ID EM:05827) in which the Amphioxus Pax3/7 cDNA followed by the IRESLacZ gene has been introduced in the Pax3 locus. To generate this line, B6.Pax3Amphi37-ILZ/+ have been crossed with a FLP-expressing line (removing the LacZ gene). Floxed and FRT flanked cassettes have been removed: one FRT and one loxP site remain in the genome. |
Phenotypic information | The heterozygous mice are viable, fertile and present a white belly spot. Homozygous lethality. |
Breeding history | Heterozygotes are viable and fertile. Homozygous lethality. Heterozygous males are crossed to C57BL/6 females. The line has been backcrossed to C57BL/6 background for at least 5 generations. |
References | None available |
Homozygous fertile | no |
Homozygous viable | no |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | Institut de Transgenose, INTRAGENE, Orléans, France |
Animals used for archiving | heterozygous C57BL/6J |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Craniofacial-deafness-hand syndrome / Orphanet_1529
- Waardenburg syndrome type 1 / Orphanet_894
- Waardenburg syndrome type 3 / Orphanet_896
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