IMPC phenotypes (allele matching)
C57BL/6N-Atm1Brd Cfhtm1a(EUCOMM)Wtsi/WtsiH
| Status | Available to order |
| EMMA ID | EM:05871 |
| Citation information | RRID:IMSR_EM:05871 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | C57BL/6N-Atm1Brd Cfhtm1a(EUCOMM)Wtsi/WtsiH |
| Alternative name | EPD0424_5_A05 |
| Strain type | Targeted Mutant Strains |
| Allele/Transgene symbol | Cfhtm1a(EUCOMM)Wtsi |
| Gene/Transgene symbol | Cfh |
| Disclaimer | Please note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
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Information from provider
| Provider | Wellcome Trust Sanger Institute |
| Provider affiliation | Wellcome Trust Sanger Institute |
| Genetic information | This mouse line originates from EUCOMM ES clone EPD0424_5_A05. For further details on the construction of this clone see the page at the IMPC portal. |
| Phenotypic information | Potential phenotyping data in the IMPC portal |
| References | None available |
Information from EMMA
| Archiving centre | Mary Lyon Centre at MRC Harwell, Oxford, United Kingdom |
| Animals used for archiving | homozygous C57BL/6NTac males |
| Breeding at archiving centre | Frozen material received. Due to the possible presence of C57BL/6N-Atm1Brd/a, may produce agouti pups. |
Disease and phenotype information
MGI phenotypes (allele matching)
- increased mean corpuscular hemoglobin / MGI
MGI phenotypes (gene matching)
- abnormal retinal photoreceptor morphology / MGI
- abnormal retina morphology / MGI
- premature death / MGI
- glomerulonephritis / MGI
- albuminuria / MGI
- increased urine protein level / MGI
- amyloid beta deposits / MGI
- abnormal retinal layer morphology / MGI
- hematuria / MGI
- abnormal retinal pigment epithelium morphology / MGI
- abnormal Bruch membrane morphology / MGI
- abnormal renal glomerulus morphology / MGI
- abnormal circulating protein level / MGI
- increased mean corpuscular hemoglobin / MGI
- increased susceptibility to type III hypersensitivity reaction / MGI
- abnormal retinal rod bipolar cell morphology / MGI
- decreased visual acuity / MGI
- disorganized photoreceptor outer segment / MGI
- abnormal kidney capillary morphology / MGI
- abnormal renal glomerulus basement membrane morphology / MGI
- expanded mesangial matrix / MGI
- mesangial cell hyperplasia / MGI
- mesangial cell interposition / MGI
- abnormal complement protein level / MGI
- decreased a wave amplitude / MGI
- decreased b wave amplitude / MGI
- decreased circulating complement protein level / MGI
- renal glomerular protein deposits / MGI
- renal glomerular immunoglobulin deposits / MGI