C57BL/6N-Fstl1tm1a(EUCOMM)Hmgu/Cnrm

Status

Available to order

EMMA IDEM:05961
Citation informationRRID:IMSR_EM:05961 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Fstl1tm1a(EUCOMM)Hmgu/Cnrm
Alternative nameHEPD0638_3_B07
Strain typeTargeted Mutant Strains
Allele/Transgene symbolFstl1tm1a(EUCOMM)Hmgu
Gene/Transgene symbolFstl1
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider CNR, Consiglio Nazionale delle Ricerche
Provider affiliationEMMA-Monterotondo Campus International Development, CNR, Consiglio Nazionale delle Ricerche
Genetic informationThis mouse line originates from EUCOMM ES clone HEPD0638_3_B07. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

IMPC phenotypes (gene matching)
  • impaired glucose tolerance / IMPC
  • increased circulating HDL cholesterol level / IMPC
  • decreased fasting circulating glucose level / IMPC
  • decreased neutrophil cell number / IMPC
  • increased lymphocyte cell number / IMPC
  • increased circulating cholesterol level / IMPC
MGI phenotypes (gene matching)
  • abnormal rib morphology / MGI
  • hydronephrosis / MGI
  • abnormal ureter morphology / MGI
  • hydroureter / MGI
  • abnormal lung morphology / MGI
  • abnormal lung development / MGI
  • cyanosis / MGI
  • abnormal breathing pattern / MGI
  • respiratory distress / MGI
  • abnormal digit morphology / MGI
  • abnormal neural tube morphology / MGI
  • no abnormal phenotype detected / MGI
  • abnormal larynx morphology / MGI
  • abnormal bronchiole morphology / MGI
  • abnormal pulmonary alveolus morphology / MGI
  • abnormal type II pneumocyte morphology / MGI
  • abnormal trachea morphology / MGI
  • abnormal tracheal ciliated epithelium morphology / MGI
  • small kidney / MGI
  • abnormal metacarpal bone morphology / MGI
  • abnormal tracheal cartilage morphology / MGI
  • dilated ureter / MGI
  • ureter stenosis / MGI
  • abnormal ureter development / MGI
  • abnormal long bone morphology / MGI
  • abnormal hindlimb stylopod morphology / MGI
  • abnormal hindlimb zeugopod morphology / MGI
  • abnormal spine curvature / MGI
  • abnormal kidney pelvis morphology / MGI
  • pulmonary hyperplasia / MGI
  • bowed fibula / MGI
  • decreased tracheal cartilage ring number / MGI
  • abnormal cervical atlas morphology / MGI
  • abnormal cervical axis morphology / MGI
  • absent patella / MGI
  • increased glycogen level / MGI
  • abnormal skeleton morphology / MGI
  • abnormal lung epithelium morphology / MGI
  • abnormal costal cartilage morphology / MGI
  • asymmetric sternocostal joints / MGI
  • fused phalanges / MGI
  • increased type II pneumocyte number / MGI
  • decreased type I pneumocyte number / MGI
  • primary atelectasis / MGI
  • trachea stenosis / MGI
  • decreased alveolar lamellar body number / MGI
  • abnormal pulmonary alveolar sac morphology / MGI
  • abnormal lung lobe morphology / MGI
  • decreased surfactant secretion / MGI
  • neonatal lethality, complete penetrance / MGI
  • perinatal lethality, complete penetrance / MGI
  • kidney papillary atrophy / MGI
  • abnormal ureter urothelium morphology / MGI
  • camptomelia / MGI
  • decreased bone ossification / MGI
  • absent sesamoid bone of gastrocnemius / MGI

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen sperm. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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