CD1.129-Nogtm1Amc/Orl

Status

Available to order

EMMA IDEM:05988
International strain nameCD1.129-Nogtm1Amc/Orl
Alternative nameNogtm1Amc
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolNogtm1Amc,
Gene/Transgene symbolNog

Information from provider

ProviderPrzemko Tylzanowski
Provider affiliationDevelopment Growth and Regeneration, University of Leuven
Genetic informationGene targeting generated a null allele by fusing the first 10 amino acids of coding sequence in-frame to the lacZ gene. The remainder of the coding sequence and some of the 3' flanking sequence of the gene were deleted.
Phenotypic informationThe noggin null embryos have multiple defects including a failure of neural tube closure, broad club-shaped limbs, loss of caudal vertebrae, a shortened body axis, and retention of a small vestigial tail.
Breeding historyBackcrossed into CD1 background for more than 20 generations.
References
  • Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton.;Brunet L J, McMahon J A, McMahon A P, Harland R M, ;1998;Science (New York, N.Y.);280;1455-7; 9603738
  • The Noggin null mouse phenotype is strain dependent and haploinsufficiency leads to skeletal defects.;Tylzanowski Przemko, Mebis Liese, Luyten Frank P, ;2006;Developmental dynamics : an official publication of the American Association of Anatomists;235;1599-607; 16598734
Homozygous fertileno
Homozygous viableno
Homozygous matings requiredno
Immunocompromisedno

Information from EMMA

Archiving centreInstitut de Transgenose, INTRAGENE, Orléans, France
Animals used for archivingheterozygous CD-1 outbred stock (syn.: outbr. CD-1 or CD1, Swiss CD-1 or CD1, ICR(CD-1), etc.)

Disease and phenotype information

MGI allele-associated human disease models

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • abnormal middle ear morphology / MGI
  • abnormal rib morphology / MGI
  • kinked tail / MGI
  • fused synovial joints / MGI
  • conductive hearing loss / MGI
  • abnormal middle ear ossicle morphology / MGI
  • abnormal stapes morphology / MGI
  • impaired hearing / MGI
  • abnormal styloid process morphology / MGI
  • small thoracic cage / MGI
  • increased or absent threshold for auditory brainstem response / MGI
  • kyphosis / MGI
  • abnormal axial skeleton morphology / MGI
  • hearing/vestibular/ear phenotype / MGI
  • small prostate gland ventral lobe / MGI
  • exencephaly / MGI
  • perinatal lethality / MGI
  • abnormal malleus morphology / MGI
  • fusion of middle ear ossicles / MGI
  • small limb buds / MGI
  • abnormal incus morphology / MGI
  • lethality throughout fetal growth and development, complete penetrance / MGI
  • abnormal craniofacial morphology / MGI
  • abnormal neural tube morphology / MGI
  • abnormal skeleton morphology / MGI
  • perinatal lethality, complete penetrance / MGI
  • short face / MGI
  • abnormal interparietal bone morphology / MGI
  • abnormal frontal bone morphology / MGI
  • abnormal parietal bone morphology / MGI
  • short limbs / MGI
  • incomplete rostral neuropore closure / MGI
  • open neural tube / MGI
  • wavy neural tube / MGI
  • abnormal spinal cord morphology / MGI
  • abnormal lung morphology / MGI
  • abnormal lung development / MGI
  • abnormal somite development / MGI
  • kinked neural tube / MGI
  • absent tail / MGI
  • abnormal neural tube closure / MGI
  • abnormal vertebral arch morphology / MGI
  • absent vertebral arch / MGI
  • abnormal occipital bone morphology / MGI
  • spina bifida occulta / MGI
  • abnormal neural plate morphology / MGI
  • increased apoptosis / MGI
  • abnormal right lung morphology / MGI
  • abnormal basicranium morphology / MGI
  • edema / MGI
  • abnormal muscle morphology / MGI
  • abnormal limb morphology / MGI
  • vestigial tail / MGI
  • abnormal bone mineralization / MGI
  • abnormal hair follicle development / MGI
  • abnormal muscle fiber morphology / MGI
  • decreased fetal size / MGI
  • abnormal limb bud morphology / MGI
  • hematoma / MGI
  • abnormal cochlea morphology / MGI
  • decreased cochlear coiling / MGI
  • increased cochlear inner hair cell number / MGI
  • increased cochlear outer hair cell number / MGI
  • abnormal eye development / MGI
  • decreased embryo size / MGI
  • abnormal notochord morphology / MGI
  • abnormal ear development / MGI
  • abnormal rostral-caudal patterning of the somites / MGI
  • decreased somite size / MGI
  • abnormal foregut morphology / MGI
  • abnormal esophagus development / MGI
  • esophageal atresia / MGI
  • tracheoesophageal fistula / MGI
  • esophagus stenosis / MGI
  • abnormal head morphology / MGI
  • abnormal diencephalon morphology / MGI
  • abnormal pituitary gland development / MGI
  • absent pituitary gland / MGI
  • abnormal pituitary gland physiology / MGI
  • absent adenohypophysis / MGI
  • absent Rathke's pouch / MGI
  • abnormal Rathke's pouch development / MGI
  • abnormal Rathke's pouch apoptosis / MGI
  • absent pituitary infundibular stalk / MGI
  • abnormal urethra morphology / MGI
  • abnormal male reproductive system morphology / MGI
  • abnormal prostate gland morphology / MGI
  • cryptorchism / MGI
  • absent bulbourethral gland / MGI
  • abnormal septation of the cloaca / MGI
  • anal atresia / MGI
  • abnormal urinary system development / MGI
  • abnormal prostate gland development / MGI
  • abnormal primitive urogenital sinus morphology / MGI
  • pelvic kidney / MGI

Literature references

  • Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton.;Brunet L J, McMahon J A, McMahon A P, Harland R M, ;1998;Science (New York, N.Y.);280;1455-7; 9603738
  • The Noggin null mouse phenotype is strain dependent and haploinsufficiency leads to skeletal defects.;Tylzanowski Przemko, Mebis Liese, Luyten Frank P, ;2006;Developmental dynamics : an official publication of the American Association of Anatomists;235;1599-607; 16598734

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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