- decreased hematocrit / MGI
- hypertension / MGI
- anemia / MGI
- reticulocytosis / MGI
- poikilocytosis / MGI
- microcytosis / MGI
- decreased hemoglobin content / MGI
- abnormal erythrocyte osmotic lysis / MGI
- increased spleen weight / MGI
- increased circulating bilirubin level / MGI
- decreased mean corpuscular hemoglobin / MGI
- increased mean corpuscular hemoglobin concentration / MGI
- increased systemic arterial diastolic blood pressure / MGI
- increased systemic arterial systolic blood pressure / MGI
- increased pulse pressure / MGI
B6.129-Add2tm1Feb/Cnrm
Status | Available to order |
EMMA ID | EM:00006 |
International strain name | B6.129-Add2tm1Feb/Cnrm |
Alternative name | Add2-KO |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Add2tm1Feb, |
Gene/Transgene symbol | Add2 |
Information from provider
Provider | Francisco E. Baralle |
Provider affiliation | ICGEB-Inter.Centre Genetic Engineering Biotechnology |
Genetic information | Replacement (deletion) of Add2 exons 7 to 13 by the neomycin resistance gene. |
Phenotypic information | Phenotype defects: spherocytic hereditary elliptocytosis (SHE), hypertension. |
Breeding history | Backcrossed to C57BL/6 (6 generations). |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
MGI phenotypes (allele matching)
Literature references
- Mild spherocytic hereditary elliptocytosis and altered levels of alpha- and gamma-adducins in beta-adducin-deficient mice.;Muro A F, Marro M L, Gajović S, Porro F, Luzzatto L, Baralle F E, ;2000;Blood;95;3978-85; 10845937
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