B6.129-Add2tm1Feb/Cnrm

Status

Available to order

EMMA IDEM:00006
International strain nameB6.129-Add2tm1Feb/Cnrm
Alternative nameAdd2-KO
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolAdd2tm1Feb,
Gene/Transgene symbolAdd2

Information from provider

ProviderFrancisco E. Baralle
Provider affiliationICGEB-Inter.Centre Genetic Engineering Biotechnology
Genetic informationReplacement (deletion) of Add2 exons 7 to 13 by the neomycin resistance gene.
Phenotypic informationPhenotype defects: spherocytic hereditary elliptocytosis (SHE), hypertension.
Breeding historyBackcrossed to C57BL/6 (6 generations).
References
  • Mild spherocytic hereditary elliptocytosis and altered levels of alpha- and gamma-adducins in beta-adducin-deficient mice.;Muro A F, Marro M L, Gajović S, Porro F, Luzzatto L, Baralle F E, ;2000;Blood;95;3978-85; 10845937

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

MGI phenotypes (allele matching)
  • decreased hematocrit / MGI
  • hypertension / MGI
  • anemia / MGI
  • reticulocytosis / MGI
  • poikilocytosis / MGI
  • microcytosis / MGI
  • decreased hemoglobin content / MGI
  • abnormal erythrocyte osmotic lysis / MGI
  • increased spleen weight / MGI
  • increased circulating bilirubin level / MGI
  • decreased mean corpuscular hemoglobin / MGI
  • increased mean corpuscular hemoglobin concentration / MGI
  • increased systemic arterial diastolic blood pressure / MGI
  • increased systemic arterial systolic blood pressure / MGI
  • increased pulse pressure / MGI

Literature references

  • Mild spherocytic hereditary elliptocytosis and altered levels of alpha- and gamma-adducins in beta-adducin-deficient mice.;Muro A F, Marro M L, Gajović S, Porro F, Luzzatto L, Baralle F E, ;2000;Blood;95;3978-85; 10845937

Information on how we integrate external resources can be found here

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
For this strain no provider MTA is needed. Distribution is based on the EMMA conditions only.

EMMA conditions
Legally binding conditions for the transfer

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