MGI phenotypes (allele matching)
B6.129P2(SJL)-Gjd3tm2.1Kwi/Cnrm
| Status | Available to order |
| EMMA ID | EM:06026 |
| International strain name | B6.129P2(SJL)-Gjd3tm2.1Kwi/Cnrm |
| Alternative name | Cx30.2YFP |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Gjd3tm2.1Kwi, |
| Gene/Transgene symbol | Gjd3 |
Information from provider
| Provider | Klaus Willecke |
| Provider affiliation | LIMES Institute, University of Bonn |
| Genetic information | The coding region of connexin 30.2 (Gjd3) was deleted and replaced by a YFP reporter gene. |
| Phenotypic information | Homozygous Cx30.2YFP mice show a faster impulse propagation through the atrioventricular node. |
| Breeding history | The line was backcrossed at least five times to C57BL/6 mice. |
| References |
|
| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Literature references
- Connexin45 provides optimal atrioventricular nodal conduction in the adult mouse heart.;Frank Marina, Wirth Angela, Andrié René P, Kreuzberg Maria M, Dobrowolski Radoslaw, Seifert Gerald, Offermanns Stefan, Nickenig Georg, Willecke Klaus, Schrickel Jan W, ;2012;Circulation research;111;1528-38; 22982984