- increased susceptibility to experimental autoimmune encephalomyelitis / MGI
- abnormal blood-brain barrier function / MGI
- decreased T cell apoptosis / MGI
- absent circulating adrenaline / MGI
- decreased circulating noradrenaline level / MGI
- abnormal adrenal chromaffin cell morphology / MGI
- decreased erythroid progenitor cell number / MGI
- neonatal lethality, complete penetrance / MGI
- abnormal osteoblast physiology / MGI
- skeleton phenotype / MGI
- abnormal osteoblast differentiation / MGI
B6.129P2/Ola-Nr3c1tm2.1Gsc/Cnrm
Status | Available to order |
EMMA ID | EM:00608 |
International strain name | B6.129P2/Ola-Nr3c1tm2.1Gsc/Cnrm |
Alternative name | GRnull |
Strain type | Targeted Mutant Strains : Knock-out |
Allele/Transgene symbol | Nr3c1tm2.1Gsc, |
Gene/Transgene symbol | Nr3c1 |
Information from provider
Provider | Günther Schütz |
Provider affiliation | Molecular Biology of the Cell I, German Cancer Research Center |
Genetic information | Removal of the floxed first Zn-finger domain sequence (exon 3, flanked by loxP sites) by crossing with a cre recombinase-deleter mouse. |
Phenotypic information | Failure of lung inflation after birth. Hypothalamic-pituitary-adrenal (HPA) axis alteration. Skin defects. |
References |
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Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Disease and phenotype information
Orphanet associated rare diseases, based on orthologous gene matching
- Generalized glucocorticoid resistance syndrome / Orphanet_786
MGI phenotypes (allele matching)
Literature references
- Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells.;Finotto S, Krieglstein K, Schober A, Deimling F, Lindner K, Brühl B, Beier K, Metz J, Garcia-Arraras J E, Roig-Lopez J L, Monaghan P, Schmid W, Cole T J, Kellendonk C, Tronche F, Schütz G, Unsicker K, ;1999;Development (Cambridge, England);126;2935-44; 10357937
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