B6.129P2/Ola-Nr3c1tm2.1Gsc/Cnrm

Status

Available to order

EMMA IDEM:00608
International strain nameB6.129P2/Ola-Nr3c1tm2.1Gsc/Cnrm
Alternative nameGRnull
Strain typeTargeted Mutant Strains : Knock-out
Allele/Transgene symbolNr3c1tm2.1Gsc,
Gene/Transgene symbolNr3c1

Information from provider

ProviderGünther Schütz
Provider affiliationMolecular Biology of the Cell I, German Cancer Research Center
Genetic informationRemoval of the floxed first Zn-finger domain sequence (exon 3, flanked by loxP sites) by crossing with a cre recombinase-deleter mouse.
Phenotypic informationFailure of lung inflation after birth. Hypothalamic-pituitary-adrenal (HPA) axis alteration. Skin defects.
References
  • Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells.;Finotto S, Krieglstein K, Schober A, Deimling F, Lindner K, Brühl B, Beier K, Metz J, Garcia-Arraras J E, Roig-Lopez J L, Monaghan P, Schmid W, Cole T J, Kellendonk C, Tronche F, Schütz G, Unsicker K, ;1999;Development (Cambridge, England);126;2935-44; 10357937

Information from EMMA

Archiving centreCNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy

Disease and phenotype information

Orphanet associated rare diseases, based on orthologous gene matching

MGI phenotypes (allele matching)
  • increased susceptibility to experimental autoimmune encephalomyelitis / MGI
  • abnormal blood-brain barrier function / MGI
  • decreased T cell apoptosis / MGI
  • absent circulating adrenaline / MGI
  • decreased circulating noradrenaline level / MGI
  • abnormal adrenal chromaffin cell morphology / MGI
  • decreased erythroid progenitor cell number / MGI
  • neonatal lethality, complete penetrance / MGI
  • abnormal osteoblast physiology / MGI
  • skeleton phenotype / MGI
  • abnormal osteoblast differentiation / MGI

Literature references

  • Analysis of mice carrying targeted mutations of the glucocorticoid receptor gene argues against an essential role of glucocorticoid signalling for generating adrenal chromaffin cells.;Finotto S, Krieglstein K, Schober A, Deimling F, Lindner K, Brühl B, Beier K, Metz J, Garcia-Arraras J E, Roig-Lopez J L, Monaghan P, Schmid W, Cole T J, Kellendonk C, Tronche F, Schütz G, Unsicker K, ;1999;Development (Cambridge, England);126;2935-44; 10357937

Order

Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

  • Frozen embryos. Delivered in 4 weeks (after paperwork in place). €1740*
  • Rederivation of mice from frozen stock, delivery time available upon request . €3880*

Due to the dynamic nature of our processes strain availability may change at short notice. The local repository manager will advise you in these circumstances.

* In addition users have to cover all the shipping costs (including the cost for returning dry-shippers, where applicable).

More details on pricing and delivery times

Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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