C57BL/6N-Atm1Brd Mapk10tm1a(EUCOMM)Wtsi/WtsiCnbc

Status

Available to order

EMMA IDEM:06099
Citation informationRRID:IMSR_EM:06099 

Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information.

 
International strain nameC57BL/6N-Atm1Brd Mapk10tm1a(EUCOMM)Wtsi/WtsiCnbc
Alternative nameEPD0666_3_D10
Strain typeTargeted Mutant Strains
Allele/Transgene symbolMapk10tm1a(EUCOMM)Wtsi
Gene/Transgene symbolMapk10
DisclaimerPlease note that for EUCOMM and KOMP-CSD mice supplied to the scientific community by INFRAFRONTIER/EMMA:
  1. We can not guarantee a null mutation for Knock-out first alleles (tm1a alleles, see http://www.mousephenotype.org/about-ikmc/targeting-strategies) as the critical exon has not been deleted.
  2. That the structure of the targeted mutation in the ES cells obtained from EUCOMM/KOMP to generate EUCOMM/KOMP mice is not verified by INFRAFRONTIER/EMMA. It is recommended that the recipient confirms the mutation structure.
  3. No check for determining the copy number of the targeting construct in ES cells obtained from EUCOMM/KOMP is done by INFRAFRONTIER/EMMA.
  4. The level of quality control before mice are released is to confirm the individual mouse genotype by short range PCR.

Information from provider

Provider Wellcome Trust Sanger Institute
Provider affiliationWellcome Trust Sanger Institute
Genetic informationThis mouse line originates from EUCOMM ES clone EPD0666_3_D10. For further details on the construction of this clone see the page at the IMPC portal.
Phenotypic informationPotential phenotyping data in the IMPC portal
ReferencesNone available

Information from EMMA

Archiving centreCNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain
Animals used for archivinghomozygous C57BL/6NTac males

Disease and phenotype information

MGI phenotypes (gene matching)
  • abnormal cell death / MGI
  • abnormal somatic motor system morphology / MGI
  • impaired coordination / MGI
  • abnormal dopamine level / MGI
  • decreased susceptibility to pharmacologically induced seizures / MGI
  • no phenotypic analysis / MGI
  • decreased neuron apoptosis / MGI
  • cardiovascular system phenotype / MGI
  • decreased susceptibility to neuronal excitotoxicity / MGI
  • decreased susceptibility to dopaminergic neuron neurotoxicity / MGI

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Availabilities

Requesting frozen sperm or embryos is generally advisable wherever possible, in order to minimise the shipment of live mice.

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Practical information

Genotyping protocol

Example health report
(Current health report will be provided later)

Material Transfer Agreement (MTA)
Distribution of this strain is subject to a provider MTA. Both signing of the MTA and submission of the online EMMA Mutant Request Form are required before material can be shipped.

EMMA conditions
Legally binding conditions for the transfer

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