B6D2-Tg(KRT14-SFN)44Odo/Cnrm
Status | Available to order |
EMMA ID | EM:06111 |
International strain name | B6D2-Tg(KRT14-SFN)44Odo/Cnrm |
Alternative name | TG/K14-14,3,3sigma |
Strain type | Transgenic Strains |
Allele/Transgene symbol | Tg(KRT14-SFN)44Odo, |
Gene/Transgene symbol | Tg(KRT14-SFN)44Odo |
Information from provider
Provider | Teresa Odorisio |
Provider affiliation | Lab. Biologia Molecolare e Cellulare, Istituto Dermopatico dell'Immacolata |
Genetic information | Transgenic line overexpressing the human stratifin (14-3-3sigma) gene under the control of the keratin 14 (K14) promoter. |
Phenotypic information | Adult transgenic mice show decreased epidermal thickness and hair follicle density, reduced number of proliferating keratinocytes and keratinocyte progenitor cells. |
Breeding history | Mice have always been on a B6D2F1 background. Current generation is F19. Mice are currently bred as heterozygous, mating with B6D2F1 wt mice. |
References |
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Homozygous fertile | not known |
Homozygous viable | not known |
Homozygous matings required | no |
Immunocompromised | no |
Information from EMMA
Archiving centre | CNR, Consiglio Nazionale delle Ricerche, Monterotondo, Italy |
Literature references
- Impaired keratinocyte proliferative and clonogenic potential in transgenic mice overexpressing 14-3-3σ in the epidermis.;Cianfarani Francesca, Bernardini Silvia, De Luca Naomi, Dellambra Elena, Tatangelo Laura, Tiveron Cecilia, Niessen Carien M, Zambruno Giovanna, Castiglia Daniele, Odorisio Teresa, ;2011;The Journal of investigative dermatology;131;1821-9; 21654836
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