MGI phenotypes (allele matching)
B6.129-Sertad1tm1Srn/Cnbc
| Status | Available to order |
| EMMA ID | EM:06217 |
| Citation information | RRID:IMSR_EM:06217 Research Resource Identifiers (RRID) are persistent unique ID numbers assigned to help researchers cite key resources (e.g. antibodies, model organisms and software projects) in the biomedical literature to improve transparency and reproducibility in research. See https://www.rrids.org/ for more information. |
| International strain name | B6.129-Sertad1tm1Srn/Cnbc |
| Alternative name | Sertad1 |
| Strain type | Targeted Mutant Strains : Knock-out |
| Allele/Transgene symbol | Sertad1tm1Srn |
| Gene/Transgene symbol | Sertad1 |
Information from provider
| Provider | Manuel Serrano |
| Provider affiliation | Molecular Oncology, CNIO (Spanish National Cancer Research Centre) |
| Genetic information | Exon 2 was replaced with a neo cassette. The absence of transcript expression was confirmed by Northern blot analysis on ES cell extracts. |
| Phenotypic information | Sei1 (Sertad1) null mice are viable, do not present overt pathologies, have a normal lifespan, and have a normal susceptibility to spontaneous and chemically-induced cancer. Sei1 is highly expressed in pancreatic islets compared to other tissues. Interestingly, Sei1-null mice present lower number of islets, decreased beta-cell area, impaired insulin secretion, and glucose intolerance. |
| Breeding history | The Sei1 mouse line has been backcrossed more than 9 generations to C57BL/6J. |
| References |
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| Homozygous fertile | yes |
| Homozygous viable | yes |
| Homozygous matings required | no |
| Immunocompromised | no |
Information from EMMA
| Archiving centre | CNB-CSIC, Centro Nacional de Biotecnologia, Madrid, Spain |
| Animals used for archiving | homozygous C57BL/6J males, wild-type C57BL/6J females |
| Stage of embryos | 2-cell |
Disease and phenotype information
Literature references
- Normal proliferation and tumorigenesis but impaired pancreatic function in mice lacking the cell cycle regulator sei1.;Fernandez-Marcos Pablo J, Pantoja Cristina, Gonzalez-Rodriguez Agueda, Martin Nicholas, Flores Juana M, Valverde Angela M, Hara Eiji, Serrano Manuel, ;2010;PloS one;5;e8744; 20090907